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Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Objective

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks.
New insights from (a)+(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.

Key deliverables are:
1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3)
2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4)
3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5)
4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6)
5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7)
6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Address
Geschwister-scholl-platz
72074 Tuebingen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 360 875

Participants (13)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 962 250
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 360 000
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 539 375
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE BORDEAUX
France
EU contribution
€ 416 875
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 501 992,11
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION
Spain
EU contribution
€ 320 531
Address
Carrer Horaci 41/43 Esc B
08022 Barcelona
Activity type
Research Organisations
PRO RETINA DEUTSCHLAND
Germany
EU contribution
€ 106 250
Address
Vaalser Strasse 108
52074 Aachen
Activity type
Other
AYOXXA BIOSYSTEMS GMBH
Germany
EU contribution
€ 608 500
Address
Nattermannallee 1
50829 Cologne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST

Participation ended

United Kingdom
EU contribution
€ 124,38
Address
City Road 162
EC1V 2PD London
Activity type
Research Organisations
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Spain
EU contribution
€ 198 607,50
Address
Avenida Americo Vespucio 15 Edif S2
41092 Sevilla
Activity type
Research Organisations
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 592 116,01
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 5 000
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments