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Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Objective

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks.
New insights from (a)+(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.

Key deliverables are:
1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3)
2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4)
3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5)
4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6)
5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7)
6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Net EU contribution
€ 1 360 875,00
Address
Geschwister-scholl-platz
72074 Tuebingen
Germany

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (14)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 962 250,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
Net EU contribution
€ 360 000,00
Address
Carrer Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 539 375,00
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITE DE BORDEAUX
France
Net EU contribution
€ 264 375,00
Address
Place Pey Berland 35
33000 Bordeaux

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 152 500,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 501 992,11
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION
Spain
Net EU contribution
€ 320 531,00
Address
Carrer Horaci 41/43 Esc B
08022 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,25
PRO RETINA DEUTSCHLAND
Germany
Net EU contribution
€ 106 250,00
Address
Vaalser Strasse 108
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Other
Other funding
€ 0,00
AYOXXA BIOSYSTEMS GMBH
Germany
Net EU contribution
€ 608 500,00
Address
Nattermannallee 1
50829 Cologne

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
F. HOFFMANN-LA ROCHE AG
Switzerland
Net EU contribution
€ 0,00
Address
Grenzacherstrasse 124
4070 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 97 500,00
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST

Participation ended

United Kingdom
Net EU contribution
€ 124,38
Address
City Road 162
EC1V 2PD London
Region
London Inner London — East Haringey and Islington
Activity type
Research Organisations
Other funding
€ 0,00
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P.
Spain
Net EU contribution
€ 198 607,50
Address
Avenida Americo Vespucio 15 Edif S2
41092 Sevilla

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Region
Andalucía Sevilla
Activity type
Research Organisations
Other funding
€ 0,00
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
Net EU contribution
€ 592 116,01
Address
University Road Lanyon Building
BT7 1NN Belfast

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Region
Northern Ireland Northern Ireland Belfast
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 5 000,00
Address
Belfield
4 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00