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Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

Objective

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.

Field of science

  • /social sciences/sociology/governance/crisis management
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/toxicology

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 089 181,25

Participants (12)

KARLSTADS UNIVERSITET
Sweden
EU contribution
€ 1 194 481,25
Address
Universitetsgatan 2
651 88 Karlstad
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 316 750
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 585 000
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 450 061,25
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 418 532,50
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 428 436,25
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 62 500
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 321 250
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 350 537,50
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 489 000
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 265 570
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
OREBRO UNIVERSITY
Sweden
EU contribution
€ 252 030
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments