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PARAGONE: vaccines for animal parasites

Objective

Helminth and ectoparasitic infections of ruminants and poultry have a huge impact on the biological efficiency of these vital food sources. Indiscriminate antiparasitic use has led to drug resistance across the globe. The main alternative to the dwindling supply of antiparasitics is vaccines. Here, in the PARAGONE project, findings from previous EU and other-funded projects on parasite vaccine development will be exploited to take a number of promising prototypes towards commercialisation. Partners from the Europe, China, Uruguay, SMEs and pharma, will directly move forward prototypes against the ruminant helminths Fasciola hepatica, Cooperia spp., Ostertagia ostertagi, Teladorsagia circumcincta and Haemonchus contortus and, the ectoparasitic mites, Psoroptes ovis (ruminants) and Dermanyssus gallinae (poultry). They will utilise novel adjuvants or delivery systems to maximise efficacy of some of the prototypes. Moreover, immunology studies will focus on pathogens that have previously proved problematic, often because they release immunosuppressive molecules that must be overcome for vaccines to work or because recombinant vaccines have failed to elicit protection observed with native prototypes. State-of-the-art technologies will be used to interrogate host/parasite interactions to define key signatures of protection that can be used to inform delivery systems that will enhance immunity, while other studies will define polymorphism in current vaccine candidates to ensure derived prototypes will be fit-for-purpose across geographic scales. Fundamental, is engagement of the scientists with pharma and other stakeholders (farmers, veterinarians, regulators) via many dissemination activities that will be used to obtain feedback on how the vaccines can be best deployed in the field. The output will be at least two prototypes to the point of uptake by pharma, government or philanthropic agencies, and a clear pathway to commercialisation for all prototypes studied.

Call for proposal

H2020-SFS-2014-2
See other projects for this call

Coordinator

MOREDUN RESEARCH INSTITUTE
Address
Pentlands Science Park, Bush Loan
EH26 0PZ Penicuik
United Kingdom
Activity type
Research Organisations
EU contribution
€ 2 173 460,25

Participants (18)

DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 254 082,50
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 152 163,75
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA
Spain
EU contribution
€ 218 055
Address
C/ Juan De Quesada 30
35001 Las Palmas De Gran Canaria
Activity type
Higher or Secondary Education Establishments
LANZHOU VETERINARY RESEARCH INSTITUTE

Participation ended

China
EU contribution
€ 0
Address
Xujiaping 11
730046 Lanzhou, Gansu
Activity type
Higher or Secondary Education Establishments
VETERINAERINSTITUTTET - NORWEGIAN VETERINARY INSTITUTE
Norway
EU contribution
€ 97 541,25
Address
Ullevalsveien 68
0454 Oslo
Activity type
Research Organisations
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 467 786,25
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
THE ROYAL VETERINARY COLLEGE
United Kingdom
EU contribution
€ 433 842,50
Address
Royal College Street
NW1 OTU London
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 855 338,25
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE CORDOBA
Spain
EU contribution
€ 782 932,78
Address
Avenida De Medina Azahara 5
14005 Cordoba
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE LA REPUBLICA
Uruguay
EU contribution
€ 531 250
Address
Avenida 18 De Julio 1824
11200 Montevideo
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 1 322 233,75
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
BENCHMARK ANIMAL HEALTH LIMITED
United Kingdom
EU contribution
€ 490 760
Address
Benchmark House 8 Smithy Wood Drive
S35 1QN Sheffield
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Fios Genomics Limited
United Kingdom
EU contribution
€ 301 218,75
Address
Buchanan Street 166
G1 2LS Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMMUNOTOOLS GMBH
Germany
EU contribution
€ 346 750
Address
Altenoyther Str. 10
26169 Friesoythe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
XSTALBIO LTD

Participation ended

United Kingdom
EU contribution
€ 115 542,21
Address
Cids Thomson Building University Avenue
G12 8QQ Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZOETIS BELGIUM SA
Belgium
EU contribution
€ 60 000
Address
Rue Laid Burniat 1
1348 Louvain La Neuve
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 264 517,50
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 131 085,01
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments