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PARAGONE: vaccines for animal parasites

Objective

Helminth and ectoparasitic infections of ruminants and poultry have a huge impact on the biological efficiency of these vital food sources. Indiscriminate antiparasitic use has led to drug resistance across the globe. The main alternative to the dwindling supply of antiparasitics is vaccines. Here, in the PARAGONE project, findings from previous EU and other-funded projects on parasite vaccine development will be exploited to take a number of promising prototypes towards commercialisation. Partners from the Europe, China, Uruguay, SMEs and pharma, will directly move forward prototypes against the ruminant helminths Fasciola hepatica, Cooperia spp., Ostertagia ostertagi, Teladorsagia circumcincta and Haemonchus contortus and, the ectoparasitic mites, Psoroptes ovis (ruminants) and Dermanyssus gallinae (poultry). They will utilise novel adjuvants or delivery systems to maximise efficacy of some of the prototypes. Moreover, immunology studies will focus on pathogens that have previously proved problematic, often because they release immunosuppressive molecules that must be overcome for vaccines to work or because recombinant vaccines have failed to elicit protection observed with native prototypes. State-of-the-art technologies will be used to interrogate host/parasite interactions to define key signatures of protection that can be used to inform delivery systems that will enhance immunity, while other studies will define polymorphism in current vaccine candidates to ensure derived prototypes will be fit-for-purpose across geographic scales. Fundamental, is engagement of the scientists with pharma and other stakeholders (farmers, veterinarians, regulators) via many dissemination activities that will be used to obtain feedback on how the vaccines can be best deployed in the field. The output will be at least two prototypes to the point of uptake by pharma, government or philanthropic agencies, and a clear pathway to commercialisation for all prototypes studied.
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Coordinator

MOREDUN RESEARCH INSTITUTE

Address

Pentlands Science Park, Bush Loan
Eh26 0pz Penicuik

United Kingdom

Activity type

Research Organisations

EU Contribution

€ 2 173 460,25

Participants (18)

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DUBLIN CITY UNIVERSITY

Ireland

EU Contribution

€ 254 082,50

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 152 163,75

UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA

Spain

EU Contribution

€ 218 055

LANZHOU VETERINARY RESEARCH INSTITUTE

China

VETERINAERINSTITUTTET - NORWEGIAN VETERINARY INSTITUTE

Norway

EU Contribution

€ 97 541,25

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU Contribution

€ 467 786,25

THE ROYAL VETERINARY COLLEGE

United Kingdom

EU Contribution

€ 433 842,50

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 855 338,25

UNIVERSIDAD DE CORDOBA

Spain

EU Contribution

€ 782 932,78

UNIVERSIDAD DE LA REPUBLICA

Uruguay

EU Contribution

€ 531 250

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 1 322 233,75

BENCHMARK ANIMAL HEALTH LIMITED

United Kingdom

EU Contribution

€ 490 760

Fios Genomics Limited

United Kingdom

EU Contribution

€ 301 218,75

IMMUNOTOOLS GMBH

Germany

EU Contribution

€ 346 750

XSTALBIO LTD

United Kingdom

EU Contribution

€ 115 542,21

ZOETIS BELGIUM SA

Belgium

EU Contribution

€ 60 000

UNIVERSITY OF STRATHCLYDE

United Kingdom

EU Contribution

€ 264 517,50

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 131 085,01

Project information

Grant agreement ID: 635408

Status

Closed project

  • Start date

    1 April 2015

  • End date

    31 March 2019

Funded under:

H2020-EU.3.2.

  • Overall budget:

    € 8 998 559,75

  • EU contribution

    € 8 998 559,75

Coordinated by:

MOREDUN RESEARCH INSTITUTE

United Kingdom