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Sustainable industrial processes based on a C-C bond-forming enzyme platform

Ziel

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project.
Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners.
CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

Wissenschaftliches Gebiet

  • /Sozialwissenschaften/Wirtschaftswissenschaften/Business und Management/Handel

Aufforderung zur Vorschlagseinreichung

H2020-LEIT-BIO-2014-1
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

IA - Innovation action

Koordinator

TECHNISCHE UNIVERSITAT DARMSTADT
Adresse
Karolinenplatz 5
64289 Darmstadt
Deutschland
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 1 469 606

Beteiligte (14)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spanien
EU-Beitrag
€ 1 145 190
Adresse
Calle Serrano 117
28006 Madrid
Aktivitätstyp
Research Organisations
UNIVERSIDAD AUTONOMA DE MADRID
Spanien
EU-Beitrag
€ 786 375
Adresse
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Aktivitätstyp
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Deutschland
EU-Beitrag
€ 677 018
Adresse
Universitaetsplatz 2
38106 Braunschweig
Aktivitätstyp
Higher or Secondary Education Establishments
RIJKSUNIVERSITEIT GRONINGEN
Niederlande
EU-Beitrag
€ 726 452
Adresse
Broerstraat 5
9712CP Groningen
Aktivitätstyp
Higher or Secondary Education Establishments
SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE
Kroatien
EU-Beitrag
€ 544 260
Adresse
Marulicev Trg 19
10000 Zagreb
Aktivitätstyp
Higher or Secondary Education Establishments
BIOCHEMIZE SL
Spanien
EU-Beitrag
€ 207 987
Adresse
Carrer Marie Curie 8
08042 Barcelona
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIO-PRODICT BV
Niederlande
EU-Beitrag
€ 463 736
Adresse
Nieuwe Marktstraat 54
6511 AA Nijmegen
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SUSTAINABLE MOMENTUM SL
Spanien
EU-Beitrag
€ 109 200
Adresse
Avda Alcalde Jose Ramirez Bethencourt 17 Planta 6 Puerta B
35004 Las Palmas De Gran Canaria
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA
Spanien
EU-Beitrag
€ 416 325
Adresse
Calle Alvarez De Castro 63
08100 Mollet Del Valles
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENZYMICALS AG
Deutschland
EU-Beitrag
€ 380 800
Adresse
Walther-rathenau-strasse 49A
17489 Greifswald
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Deutschland
EU-Beitrag
€ 412 500
Adresse
Fahnenbergplatz
79098 Freiburg
Aktivitätstyp
Higher or Secondary Education Establishments
PROZOMIX LIMITED
United Kingdom
EU-Beitrag
€ 384 892
Adresse
Station Court 3
NE49 9HN Haltwhistle
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVONIK INDUSTRIES AG

Beteiligung beendet

Deutschland
EU-Beitrag
€ 0
Adresse
Rellinghauser Strasse 1-11
45128 Essen
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVONIK CREAVIS GMBH
Deutschland
EU-Beitrag
€ 478 625
Adresse
Rellinghauser Strasse 1-11
45128 Essen
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)