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Sustainable industrial processes based on a C-C bond-forming enzyme platform

Sustainable industrial processes based on a C-C bond-forming enzyme platform

Objective

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project.
Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners.
CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.
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Coordinator

TECHNISCHE UNIVERSITAT DARMSTADT

Address

Karolinenplatz 5
64289 Darmstadt

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 469 606

Participants (14)

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AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 1 145 190

UNIVERSIDAD AUTONOMA DE MADRID

Spain

EU Contribution

€ 786 375

TECHNISCHE UNIVERSITAET BRAUNSCHWEIG

Germany

EU Contribution

€ 677 018

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 726 452

SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE

Croatia

EU Contribution

€ 544 260

BIOCHEMIZE SL

Spain

EU Contribution

€ 207 987

BIO-PRODICT BV

Netherlands

EU Contribution

€ 463 736

SUSTAINABLE MOMENTUM SL

Spain

EU Contribution

€ 109 200

INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA

Spain

EU Contribution

€ 416 325

ENZYMICALS AG

Germany

EU Contribution

€ 380 800

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany

EU Contribution

€ 412 500

PROZOMIX LIMITED

United Kingdom

EU Contribution

€ 384 892

EVONIK INDUSTRIES AG

Germany

EVONIK CREAVIS GMBH

Germany

EU Contribution

€ 478 625

Project information

Grant agreement ID: 635595

Status

Closed project

  • Start date

    1 April 2015

  • End date

    31 March 2019

Funded under:

H2020-EU.2.1.4.

  • Overall budget:

    € 9 251 355

  • EU contribution

    € 8 202 966

Coordinated by:

TECHNISCHE UNIVERSITAT DARMSTADT

Germany