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Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics

Advanced XFEL and Synchrotron based Probes of Protein Structure and Dynamics

Objective

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology.
X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Address

Piazzale Aldo Moro 5
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 258 061,32

Participants (8)

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GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 263 659,32

XTAL CONCEPTS GMBH

Germany

EU Contribution

€ 249 216,48

EUROPEAN SYNCHROTRON RADIATION FACILITY

France

EU Contribution

€ 262 875,60

UNIVERSITAET HAMBURG

Germany

EU Contribution

€ 249 216,48

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 263 659,32

MOLIROM SRL

Italy

EU Contribution

€ 258 061,32

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 262 875,60

ASTRAZENECA AB

Sweden

EU Contribution

€ 263 659,32

Partners (2)

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PAUL SCHERRER INSTITUT

SAPIENZA INNOVAZIONE CONSORZIO

Project information

Grant agreement ID: 637295

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2018

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 331 284,76

  • EU contribution

    € 2 331 284,76

Coordinated by:

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy