Description du projet DEENESFRITPL Examen approfondi de la régénération du tissu cornéen La cécité cornéenne impose un fardeau économique et social important à des millions de personnes dans le monde. Alors que les greffes de cornée offrent un espoir de restauration de la vision, la rareté des donneurs de cornées appropriées nécessite l’exploration de traitements alternatifs. Les approches antérieures de l’ingénierie du tissu cornéen reposaient sur des cellules de donneurs et sur une culture in vitro prolongée, ce qui présentait des limites. Le projet EyeRegen, financé par l’UE, vise à mettre au point une nouvelle méthode de régénération du tissu cornéen. En concevant des échafaudages cornéens artificiels, EyeRegen éliminera le besoin de dons de cellules et de cultures in vitro étendues. Les échafaudages recruteront les propres cellules du patient pour régénérer la cornée après l’implantation. Ces échafaudages de biomatériaux intégreront des signaux chimiques et physiques personnalisés pour attirer les cellules et stimuler la formation de tissus, révolutionnant ainsi le domaine de la régénération de la cornée. Afficher les objectifs du projet Masquer les objectifs du projet Objectif Corneal blindness resulting from disease, physical injury or chemical burns affects millions worldwide and has a considerable economic and social impact on the lives of people across Europe. In many cases corneal transplants can restore vision however the shortage of donor corneas suitable for transplantation has necessitated the development of alternative treatments. The aim of this project is to develop a new approach to corneal tissue regeneration. Previous approaches at engineering corneal tissue have required access to donor cells and lengthy culture periods in an attempt to grow tissue in vitro prior to implantation with only limited success and at great expense. Our approach will differ fundamentally from these in that we will design artificial corneal scaffolds that do not require donated cells or in vitro culture but instead will recruit the patient’s own cells to regenerate the cornea post-implantation. These biomaterial scaffolds will incorporate specific chemical and physical cues with the deliberate aim of attracting cells and inducing tissue formation. Studies will be undertaken to examine how different chemical, biochemical, physical and mechanical cues can be used to control the behaviour of corneal epithelial, stromal and endothelial cells. Once the optimal combination of these cues has been determined, this information will be incorporated into the design of the scaffold. Recent advances in manufacturing and material processing technology will enable us to develop scaffolds with organized nanometric architectures and that incorporate controlled growth factor release mechanisms. Techniques such as 3D bio-printing and nanofiber electrospinning will be used to fabricate scaffolds. The ability of the scaffold to attract cells and promote matrix remodelling will be examined by developing an in vitro bioreactor system capable of mimicking the ocular environment and by performing in vivo tests using a live animal model. Champ scientifique engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesclinical medicineophthalmologymedical and health sciencesclinical medicinetransplantation Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-StG-2014 - ERC Starting Grant Appel à propositions ERC-2014-STG Voir d’autres projets de cet appel Régime de financement ERC-STG - Starting Grant Institution d’accueil THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Contribution nette de l'UE € 1 498 734,00 Adresse COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Irlande Voir sur la carte Région Ireland Eastern and Midland Dublin Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 498 734,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Irlande Contribution nette de l'UE € 1 498 734,00 Adresse COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Voir sur la carte Région Ireland Eastern and Midland Dublin Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 498 734,00