Periodic Reporting for period 4 - INTRAHETEROSEQ (Molecular characterization of the role of intra-tumor heterogeneity in cancer progression and metastasis)
Reporting period: 2019-11-01 to 2020-10-31
Besides these improvements, cancer continues causing around 1.7 million deaths in Europe every year, it is estimated that more than 90% are due to the direct or indirect effects of metastasis, secondary tumours produced in different organs from the original primary tumour.
Recent experiments have proved that tumours are composed of different cell populations, some of them very minoritory, molecularly distinct from the rest of the tumour and it is hypothesized that are these minority populations the origin of the treatment resistant tumours or the mestastasis.
In the present project, we have designed a new experimental strategy in mouse models to identify, separate and study independently those minority populations in order to understand which they have different that allows them to be metastatic. The overall goal is to understand the molecular basis of the metastatic potential in order to improve cancer treatment in patients.