Objective Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. Endothelial dysfunction is a hallmark of aging in the vasculature and is the underlying cause of many cardiovascular disorders, like hypertension, acute myocardial infarction and stroke. This proposal aims to better understand the molecular mechanisms behind aging that lead to endothelial dysfunction.Non-coding RNAs are emerging as novel key regulators of cellular functions and we hypothesize that non-coding RNAs contribute to vascular aging. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are regulated during aging of the cardiovascular system, including the lncRNA H19. We propose to extensively characterize the role of H19 in endothelial aging and to identify other lncRNAs that are involved in vascular aging. We will use state-of-the-art in vitro and in vivo models to assess endothelial aging and function upon gain-of-function and loss-of-function of lncRNAs.Understanding the role that H19 and other lncRNAs play in aging endothelium will highlight novel potential therapeutic targets to attenuate age-induced endothelial dysfunction. The focus on aging will also yield insight in molecular mechanisms that may have been overlooked when studying endothelial function in young cells or organisms. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicineneurologystrokenatural sciencesbiological sciencesgeneticsRNA Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-StG-2014 - ERC Starting Grant Call for proposal ERC-2014-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Host institution JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Net EU contribution € 1 499 693,71 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Germany See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 499 693,71 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany Net EU contribution € 1 499 693,71 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 499 693,71