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Metabolic flexibility: breaking down food effectively to prolong life

Pubblicazioni

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Autori: Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-02539-w

Mitochondrial quality control pathways as determinants of metabolic health

Autori: Ntsiki M. Held, Riekelt H. Houtkooper
Pubblicato in: BioEssays, Numero 37/8, 2015, Pagina/e 867-876, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500013

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans

Autori: Arwen W. Gao, Jelmi uit de Bos, Mark G. Sterken, Jan E. Kammenga, Reuben L. Smith, Riekelt H. Houtkooper
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2017.09.006

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Autori: I. A. Chatzispyrou, N. M. Held, L. Mouchiroud, J. Auwerx, R. H. Houtkooper
Pubblicato in: Cancer Research, Numero 75/21, 2015, Pagina/e 4446-4449, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-1626

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Autori: Xu Wang, Dongryeol Ryu, Riekelt H. Houtkooper, Johan Auwerx
Pubblicato in: BioEssays, Numero 37/10, 2015, Pagina/e 1045-1053, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500071

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Autori: Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble, Laurent Mouchiroud, Johan Auwerx, Ellen A A Nollen, Riekelt H Houtkooper
Pubblicato in: Nature Protocols, Numero 11/10, 2016, Pagina/e 1798-1816, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/nprot.2016.106

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Autori: Jeannette C. Bleeker, Riekelt H. Houtkooper
Pubblicato in: Journal of Inherited Metabolic Disease, Numero 39/4, 2016, Pagina/e 565-572, ISSN 0141-8955
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10545-016-9939-8

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

Autori: Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Pubblicato in: EMBO Molecular Medicine, Numero 11/9, 2019, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809854

Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels

Autori: Arwen W. Gao, Mark G. Sterken, Jelmi uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L. Snoek, Jan E. Kammenga, Riekelt H. Houtkooper
Pubblicato in: Genome Research, Numero 28/9, 2018, Pagina/e 1296-1308, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.232322.117

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Autori: Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper
Pubblicato in: Life Science Alliance, Numero 1/5, 2018, Pagina/e e201800082, ISSN 2575-1077
Editore: EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.201800082

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Autori: Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper
Pubblicato in: PLOS Genetics, Numero 15/3, 2019, Pagina/e e1007633, ISSN 1553-7404
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1007633

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Autori: Ntsiki M. Held, Eline N. Kuipers, Michel van Weeghel, Jan Bert van Klinken, Simone W. Denis, Marc Lombès, Ronald J. Wanders, Frédéric M. Vaz, Patrick C. N. Rensen, Arthur J. Verhoeven, Mariëtte R. Boon, Riekelt H. Houtkooper
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-27875-3

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Autori: Marte Molenaars, Georges E. Janssens, Evan G. Williams, Aldo Jongejan, Jiayi Lan, Sylvie Rabot, Fatima Joly, Perry D. Moerland, Bauke V. Schomakers, Marco Lezzerini, Yasmine J. Liu, Mark A. McCormick, Brian K. Kennedy, Michel van Weeghel, Antoine H.C. van Kampen, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Pubblicato in: Cell Metabolism, Numero 31/3, 2020, Pagina/e 549-563.e7, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.01.011

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Autori: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Evan G. Williams, Jiayi Lan, Michel van Weeghel, Bauke Schomakers, Henk van der Veen, Nicole N. van der Wel, Pallas Yao, William B. Mair, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Pubblicato in: Journal of Cell Biology, Numero 219/6, 2020, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201907067

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Autori: Marte Molenaars, Eileen G. Daniels, Amber Meurs, Georges E. Janssens, Riekelt H. Houtkooper
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero 375/1801, 2020, Pagina/e 20190414, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2019.0414

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Autori: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper
Pubblicato in: Mechanisms of Ageing and Development, Numero 186, 2020, Pagina/e 111212, ISSN 0047-6374
Editore: Elsevier BV
DOI: 10.1016/j.mad.2020.111212

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