Objetivo "The nuclear magnetic resonance spectroscopy (NMR) is a versatile and powerful tool, especially in chemistry and in biology. However, its limited sensitivity and small amount of suitable probe nuclei pose severe constraints on the systems that may be explored.This project aims at overcoming the above limitations by giving NMR an ultra-high sensitivity and by enlarging the NMR ""toolbox"" to dozens of nuclei across the periodic table. This will be achieved by applying the β-NMR method to the soft matter samples. The method relies on anisotropic emission of β particles in the decay of highly spin-polarized nuclei. This feature results in 10 orders of magnitude more sensitivity compared to conventional NMR and makes it applicable to elements which are otherwise difficult to investigate spectroscopically. β-NMR has been successfully applied in nuclear physics and material science in solid samples and high-vacuum environments, but never before to liquid samples placed in atmospheric pressure. With this novel approach I want to create a new universal and extremely sensitive tool to study various problems in biochemistry.The first questions which I envisage addressing with this ground-breaking and versatile method concern the interaction of essential metal ions, which are spectroscopically silent in most techniques, Mg2+, Cu+, and Zn2+, with proteins and nucleic acids. The importance of these studies is well motivated by the fact that half of the proteins in our human body contain metal ions, but their interaction mechanism and factors influencing it are still not fully understood. In this respect NMR spectroscopy is of great help: it provides information on the structure, dynamics, and chemical properties of the metal complexes, by revealing the coordination number, oxidation state, bonding situation and electronic configuration of the interacting metal.My long-term aim is to establish a firm basis for β-NMR in soft matter studies in biology, chemistry and physics." Ámbito científico natural sciencesphysical sciencestheoretical physicsparticle physicsnatural sciencesphysical sciencescondensed matter physicssoft matter physicsnatural sciencesphysical sciencesnuclear physicsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesearth and related environmental sciencesatmospheric sciencesmeteorologyatmospheric pressure Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-StG-2014 - ERC Starting Grant Convocatoria de propuestas ERC-2014-STG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-STG - Starting Grant Institución de acogida ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE Aportación neta de la UEn € 1 500 000,00 Dirección ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046 1211 GENEVE 23 Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Genève Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 500 000,00 Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE Suiza Aportación neta de la UEn € 1 500 000,00 Dirección ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046 1211 GENEVE 23 Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Genève Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 500 000,00