Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases

Objective

Many therapeutic targets are shielded behind biological barriers, limiting the possibility to reach them with conventional drugs or diagnostic probes. Biological barriers are even more problematic for most biological pharmaceutics, such as recombinant proteins, antibodies and gene therapeutics. The most promising solution to this challenge is the use of nano-vehicles for specific targeting and delivery. The aim of NABBA is to form European early stage researchers (ESR) with cutting-edge scientific knowledge in the field of nanoparticles (NP) for biomedical application, able to cross biological barriers. For this aim the project will train ESRs, focusing on key aspects of nanobiotechnology: (i) design and chemical synthesis of different types of NPs, (ii) related techniques of detection and characterization, (iii) strategies of loading, targeting and delivery of drugs or diagnostic probes; (iv) proof of principle of pharmacological activity including pharmacokinetics and biodistribution. As a peculiar feature of NABBA, strong emphasis will be devoted to molecular mechanisms ruling biological barriers under physiological and pathological conditions, in order to develop novel nano-technological expedients for their crossing. Strong emphasis will be devoted to advanced chemistry issues, enabling new synthetic strategies either for NP assembly or functionalization. Different biological barriers will be addressed. ESRs will strongly benefit from a network of internationally recognized scientists in the field of chemistry, nanobiotechnology and nanomedicine, and the participation of companies with relevant interests and expertises in the field. The planned cooperation programs between Academia and Industries will allow the circulation of ESRs and this will give them the opportunity for to get acquainted with the most advanced research in the field, the most sophisticated technologies and the most advanced Industrial manufacturing platforms and innovative strategies.

Field of science

• /medical and health sciences/basic medicine/pathology
• /medical and health sciences/medical biotechnology/nanomedicine
• /medical and health sciences/clinical medicine/cancer/pancreatic cancer
• /medical and health sciences/basic medicine/immunology

Programme(s)

• H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers

Topic(s)

• MSCA-ITN-2014-ETN - Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN)

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Address

Piazza Dell'ateneo Nuovo 1
20126 Milano
Italy

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 917 551,36

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU contribution

€ 525 751,20

Address

Rue Michel Ange 3
75794 Paris

Activity type

Research Organisations

UNIVERSITEIT UTRECHT

Netherlands

EU contribution

€ 255 374,28

Address

Heidelberglaan 8
3584 CS Utrecht

Activity type

Higher or Secondary Education Establishments

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU contribution

€ 495 745,92

Address

Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

Activity type

Higher or Secondary Education Establishments

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Germany

EU contribution

€ 498 432,96

Address

Inhoffenstrasse 7
38124 Braunschweig

Activity type

Research Organisations

ENVIROINVEST KORNYEZETVEDELMI ES BIOTECHNOLOGIAI ZARTKORUEN MUKODO RESZVENYTARASASAG

Participation ended

Hungary

EU contribution

€ 158 418,82

Address

Kertvaros Utca 2
7632 Pecs

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

Address

Raemistrasse 101
8092 Zuerich

Activity type

Higher or Secondary Education Establishments

SYLENTIS SAU

Spain

Address

Plaza Descubridor Diego De Ordas 3
28003 Madrid

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

Address

Aulich Lajos Utca 26
2100 Goedoello

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

NOVARTIS PHARMA AG

Switzerland

Address

Lichtstrasse 35
4056 Basel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)