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Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Objective

BIOGEL is set up to educate young scientists to develop innovative hydrogel chemistries and systems for biomedical applications. The first objective is to provide a platform for young researchers to undergo a well-rounded PhD education, particularly focussed on translational skills for a career focused in biomedical research and medical technology development. The second objective is to engineer functional and responsive hydrogels, which resemble specific properties of the extracellular matrix. The third objective is (i) to enhance the efficacy of medical devices by 2D biointegrative coatings that direct and orchestrate the interface to living cells and tissue and enable improved integration within the body, (ii) to advance therapeutic measures by 3D templates for tissue repair, and (iii) to enable new diagnostic tools by responsive diagnostic hydrogels. BIOGEL follows an international, interdisciplinary, and intersectoral approach organized in 9 and 8 interwoven work and training packages respectively.
The training and research parts are focused on synthetic and biohybrid macromolecules to build clinically translatable hydrogels with specific, application directed bioactivities. In order to enable efficient biohybridisation and minimal invasive application, emphasis is set on in situ gelation of precursors that do not affect the viability of cells and living tissue and that can interlink bioactive subunits to stimulate tissue regeneration, and serve as a functional component in biomedical devices. Structural incorporation of such units must be flexible, dynamic, and responsive to stimuli. This is directed to enhance cell behavior and receptor interaction, tailor the mechanical properties, and enable spatial, temporal, and topographical control of functional components. Translational aspects focus on coatings of medical devices, diagnostic hydrogels, cartilage and bone repair, tissue engineering for cardiovascular implants, and nerve regeneration.

Field of science

  • /engineering and technology/materials engineering/coating and films
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

H2020-MSCA-ITN-2014
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Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
Address
Forckenbeckstrasse 50
52074 Aachen
Germany
Activity type
Research Organisations
EU contribution
€ 1 032 448,49

Participants (8)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 510 748,56
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE VALLADOLID
Spain
EU contribution
€ 247 872,96
Address
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Activity type
Higher or Secondary Education Establishments
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU contribution
€ 511 868,16
Address
Giefinggasse 4
1210 Wien
Activity type
Research Organisations
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
EU contribution
€ 205 826,89
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki
Activity type
Research Organisations
NovioSense BV
Netherlands
EU contribution
€ 255 374,28
Address
Transistorweg 5
6534 AT Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PEPSCAN THERAPEUTICS BV
Netherlands
EU contribution
€ 255 374,28
Address
Zuidersluisweg 2
8243 RC Lelystad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIFETEC GROUP BV
Netherlands
EU contribution
€ 255 374,28
Address
Kennedyplein 11
5611 ZS Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Spain
EU contribution
€ 247 872,96
Address
Paseo De Belen 11
47011 Valladolid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Synolyne Pharma
Belgium
Address
Rue Haute Claire 4
4040 Herstal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP
United States
Address
3451 Walnut Street Room P 221
19104 Philadelphia
Activity type
Higher or Secondary Education Establishments
OSAKA UNIVERSITY
Japan
Address
1-1 Yamadaoka Suita
565-0871 Osaka
Activity type
Higher or Secondary Education Establishments