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European Training Network on Bone Pain

European Training Network on Bone Pain

Objective

The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is available. To address this societal challenge and the strong innovation potential, we want to form the first European platform to promote frontline research, innovation and education within bone pain. The network encompasses 5 academic and 2 industrial beneficiaries and 1 industrial partner all committed to creating an outstanding wide-ranging yet integrated training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines. We will use in vivo models of arthritic pain, cancer-induced bone pain and fracture pain to investigate the pathophysiology and novel treatment strategies. In vivo electrophysiology will be used for studying the physiology and pharmacology of pain transmission and its modulation. Transgenic mouse models will be used to tease out the specific neuronal receptor subtypes involved. Sophisticated behaviour tests will evaluate response to novel treatments. We will create a biobank of human cancer-infiltrated bone to identify specific patterns of neuronal receptor expression and to validate therapeutic targets in humans. In an extensive training effort covering both specific research skills and transferable skills, the students will obtain an interdisciplinary, state-of-the-art and innovative training from the participants, several of which have experience from international networks. The students will benefit from secondments with industrial partners and with some of the foremost pain researchers in Europe
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KOBENHAVNS UNIVERSITET

Address

Norregade 10
1165 Kobenhavn

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 580 163,76

Participants (7)

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UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 819 863,64

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 527 318,64

THE ROYAL VETERINARY COLLEGE

United Kingdom

EU Contribution

€ 546 575,76

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 255 374,28

NORDIC BIOSCIENCE A/S

Denmark

EU Contribution

€ 580 163,76

NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S

Denmark

GRUENENTHAL GMBH

Germany

EU Contribution

€ 249 216,48

Partners (1)

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TRANSPHARMATION LTD

Project information

Grant agreement ID: 642720

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2018

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 558 676,32

  • EU contribution

    € 3 558 676,32

Coordinated by:

KOBENHAVNS UNIVERSITET

Denmark