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Engineering of new-generation protein secretion systems

Objective

The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and membrane proteins. There is an overwhelming need for new production systems that can deliver these products in greater yields, with higher quality and at lower costs. The 'ProteinFactory' ETN will meet these challenges through the provision of a suite of super-secreting strains with unique capabilities. These strains will be engineered to bypass major production bottlenecks such as secretion stress, and will be capable of secreting an unprecedented range of target molecules. Equally important will be the training of a new generation of researchers, versed in Systems and Synthetic Biology approaches. The ProteinFactory project will involve extensive collaboration between 6 academic Institutes, who provide world-leading expertise in synthetic biology and protein secretion, and 5 non-academic partners who include some of the world's premier biotechnology companies. Training will be inter-sectoral from the outset, with every ESR undertaking extensive secondments within the non-academic partners in order to encourage an entrepreneurial mind-set. The project is furthermore explicitly multi-disciplinary in scope, with two of the five research work packages dominated by theoretical approaches. Based on a responsible innovation approach and with a clear focus on inter-sectoral collaboration, ProteinFactory will deliver a cohort of superbly-trained scientists, put the industrial and SME partners at the forefront of global competition and reinforce European innovation potentials with growth and job creation.

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution
€ 383 061,42
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 383 061,42

Participants (9)

UNIVERSITY OF KENT
United Kingdom
Net EU contribution
€ 546 575,76
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent

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Region
South East (England) Kent East Kent
Activity type
Higher or Secondary Education Establishments
Other funding
€ 546 575,76
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Net EU contribution
€ 525 751,20
Address
147 Rue De L'universite
75007 Paris Cedex 07

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 525 751,20
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 790 977,96
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 790 977,96
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
Net EU contribution
€ 249 216,48
Address
Unter Den Linden 6
10117 Berlin

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 249 216,48
UNIVERSITAET GREIFSWALD
Germany
Net EU contribution
€ 498 432,96
Address
Domstrasse 11
17489 Greifswald

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 498 432,96
NOVOZYMES A/S
Denmark
Net EU contribution
€ 290 081,88
Address
Krogshoejvej 36
2880 Bagsvaerd

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 290 081,88
DSM FOOD SPECIALTIES BV
Netherlands
Net EU contribution
€ 127 687,14
Address
Alexander Fleminglaan 1
2613 AX Delft

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Region
West-Nederland Zuid-Holland Delft en Westland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 127 687,14
UCB PHARMA SA
Belgium
Net EU contribution
€ 0,00
Address
Allee De La Recherche 60
1070 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CELLTECH R&D LIMITED
United Kingdom
Net EU contribution
€ 273 287,88
Address
208 Bath Road
SL1 3WE Slough

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 273 287,88

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Abera Biosciences AB
Sweden
Net EU contribution
€ 0,00
Address

Stockholm

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00