Community Research and Development Information Service - CORDIS

Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells

From 2015-01-01 to 2018-12-31, ongoing project | IMMUNOSHAPE Website

Project details

Total cost:

EUR 3 811 581

EU contribution:

EUR 3 811 581

Coordinated in:

Spain

Call for proposal:

H2020-MSCA-ITN-2014See other projects for this call

Funding scheme:

MSCA-ITN-ETN - European Training Networks

Objective

Deliverables

  • Glycan antigen library

    Library of β-glucans, α-mannans rhamnans, fucoidans polyN-acetylglucosamines (PNAG) and lipomannans synthesized by automated solid-phase synthesis

  • Murine and human CLRs

    Recombinant expression of murine and human CLRs, expression cloning of new CLRs

  • Glycodendrimers

    (Fluorescent) glycan functionalized dendritic scaffolds prepared

  • Neoglycoproteins

    BSA and OVA-glycoconjugates prepared, GFP-neoglycoproteins expressed

  • Cell surface binding

    Classification of cell surface lectins by their in vitro binding capacity

  • Glycan binding of CLRs

    Determine the glycan binding specificities of recombinant CLRs expressed in WP1

  • Website online

    Design and develop network website, regular updates on network progress and events

Publications

  • DC-SIGN as a target for drug development based on carbohydrates
    Author(s): S. Sattin, F. Fieschi and A. Bernardi
    Published in: Carbohydrate Chemistry: state of the art and challenges for drug development, 2016. Page(s) 379-394. 
  • Multivalent Lectin-Glycan Interactions in the Immune System
    Author(s): Joao T. Monteiro and Bernd Lepenies
    Published in: Multivalency: Concepts, Research and Applications, 2017. Page(s) 325-344. 

Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain

EU contribution: EUR 495 745,92


PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
20009 SAN SEBASTIAN
Spain
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Participants

GLYCODIAG
France

EU contribution: EUR 262 875,60


520 RUE DU CHANTELOUP
45520 CHEVILLY
France
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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UNIVERSITA DEGLI STUDI DI MILANO
Italy

EU contribution: EUR 258 061,32


Via Festa Del Perdono 7
20122 MILANO
Italy
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Activity type: Higher or Secondary Education Establishments

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UNIVERSITE JOSEPH FOURIER GRENOBLE 1
Participation ended
France

EU contribution: EUR 0


Avenue Centrale, Domaine Universitaire 621
38041 GRENOBLE
France
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Activity type: Higher or Secondary Education Establishments

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UNIVERSITE GRENOBLE ALPES
France

EU contribution: EUR 262 875,60


621, AVENUE CENTRALE
38401 SAINT MARTIN D'HERES
France
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Activity type: Higher or Secondary Education Establishments

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AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

EU contribution: EUR 247 872,96


CALLE SERRANO 117
28006 MADRID
Spain
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STICHTING VU
Participation ended
Netherlands

EU contribution: EUR 0


DE BOELELAAN 1105
1081 HV AMSTERDAM
Netherlands
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Activity type: Higher or Secondary Education Establishments
Administrative contact: Vincent Everts
Tel.: +31 20 5980882
Fax: +31 20 5980333

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DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

EU contribution: EUR 249 216,48


IM NEUENHEIMER FELD 280
69120 HEIDELBERG
Germany
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MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

EU contribution: EUR 249 216,48


HOFGARTENSTRASSE 8
80539 München
Germany
Activity type: Research Organisations
Administrative contact: Alexander Otte
Tel.: +493413550807

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UNIVERSITEIT LEIDEN
Netherlands

EU contribution: EUR 255 374,28


RAPENBURG 70
2311 EZ LEIDEN
Netherlands
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GLYCOUNIVERSE GMBH & CO KGAA
Germany

EU contribution: EUR 249 216,48


ARNIMALLEE 22
14195 BERLIN
Germany
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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THE UNIVERSITY OF MANCHESTER
United Kingdom

EU contribution: EUR 273 287,88


OXFORD ROAD
M13 9PL MANCHESTER
United Kingdom
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Activity type: Higher or Secondary Education Establishments

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DC4U
Netherlands

EU contribution: EUR 255 374,28


DE CORRIDOR 21E
3621 ZA BREUKELEN
Netherlands
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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MIDATECH PHARMA ESPANA SL
Spain

EU contribution: EUR 247 872,96


PARQUE TECNOLOGICO DE BIZKAIA EDIFICIO 800 2A PLANTA
48160 DERIO
Spain
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany

EU contribution: EUR 249 216,48


BUNTEWEG 2
30559 HANNOVER
Germany
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Activity type: Higher or Secondary Education Establishments

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STICHTING VUMC
Netherlands

EU contribution: EUR 255 374,28


DE BOELELAAN 1117
1081 HV AMSTERDAM
Netherlands
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Partner organisations

GLAXOSMITHKLINE VACCINES SRL
Italy
VIA FIORENTINA 1
53100 SIENA
Italy
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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