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Chromatin Dynamics in Development and Disease

Chromatin Dynamics in Development and Disease

Objective

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.
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Coordinator

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Address

N Plastira Str 100
70013 Heraklion

Greece

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 969 547,68

Participants (12)

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LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 249 216,48

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

Greece

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU Contribution

€ 164 872,51

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 273 287,88

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Spain

EU Contribution

€ 247 872,96

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 527 318,64

WEIZMANN INSTITUTE OF SCIENCE LTD

Israel

EU Contribution

€ 260 300,52

DIAGENODE

Belgium

EU Contribution

€ 250 560

UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT

Hungary

EU Contribution

€ 223 913,52

MOSAIQUES DIAGNOSTICS GMBH

Germany

EU Contribution

€ 249 216,48

AvantiCell Science Ltd

United Kingdom

EU Contribution

€ 273 287,88

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italy

EU Contribution

€ 93 188,81

Partners (4)

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EXIQON AS

LIFEGLIMMER GMBH

Yellow Research B.V.

SB Science Management UG

Project information

Grant agreement ID: 642934

Status

Closed project

  • Start date

    1 January 2015

  • End date

    31 December 2018

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 782 583,36

  • EU contribution

    € 3 782 583,36

Coordinated by:

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Greece