Community Research and Development Information Service - CORDIS

Chromatin Dynamics in Development and Disease

From 2015-01-01 to 2018-12-31, ongoing project | Chromatin3D Website

Project details

Total cost:

EUR 3 782 583,36

EU contribution:

EUR 3 782 583,36

Coordinated in:

Greece

Call for proposal:

H2020-MSCA-ITN-2014See other projects for this call

Funding scheme:

MSCA-ITN-ETN - European Training Networks

Objective

Deliverables

  • 1st Chromatin3D Summer School

    Summer schools will take place during year 2 and 4 devoted to develop specific issues in depth. The Chromatin3D PIs and invited scientists worldwide will discuss research on relevant topics. These will be mandatory for all Chromatin3D ESRs. Summer schools will be ~4 days long at a resort to isolate the group and facilitate interactions and will precede the relevant annual Chromatin3D meetings. In this way, the ESRs will be in a superb position to take full advantage and digest the excellent possibilities that an international meeting offers. Each summer school will have the participation of at least half of the Chromatin3D PIs plus 3-7 invited speakers. At least one of such invitees will focus on ethical issues and at least one on academia-industry interactions and biotech/pharma work. The first summer school will be coordinated by FORTH in collaboration with the Weizmann Institute in the island of Crete. The University of Edinburgh in collaboration with IDIBELL will coordinate the second summer school. Both summer schools will be open to 20 additional participants. Chromatin3D’s ESRs will be actively involved in organising both schools participating in the advertisement of the events and selecting external speakers.

  • Recruitment of ESRs

    ESRs will be hired within the first five months of the network contract in order to allow three years to complete a doctoral degree and to be able to participate in the training activities outlined in section B.2.2. Recruiting clever, well-educated and dedicated candidates for research in life sciences is an increasing problem for most European research institutions. We will therefore invest all possible efforts into recruiting the best candidates, from Europe as well as other parts of the world. All scientists-in-charge will form a Recruitment Committee and will have a first meeting in connection with the Initial Network Meeting (project month 1). The recruitment committee will be responsible for WP1 (“Recruitment”). This includes organizing the recruitment of 15 ESRs within the first five months. Furthermore, the committee will ensure that the recruitment procedure is in line with the principles set out in the European Charter for Researchers (http://ec.europa.eu/euraxess/index.cfm/rights/europeanCharter) and in the Code of Conduct for the Recruitment of Researchers (http://ec.europa.eu/euraxess/index.cfm/rights/codeOfConduct). Vacancies will be advertised through the Euraxess - Researchers in Motion website (ec.europa.eu/euraxess), Euro Science Jobs (www.eurosciencejobs.com), the PI’s and ETN homepages, in scientific journals, at major Academic institutions, conferences, through e-mails, e-mailing lists from relevant conferences etc. The Recruitment Committee in collaboration with the respective responsible scientist at the host organisation will draft the advertisement. Candidates will be asked to specify first, second and third priority host institutes. Advertising text will lay out the scientific and training nature of the Chromatin3D ETN, will be explicit about eligibility issues and will specifically -though not narrowly- outline the expected qualifications of applicants. All partners will be involved in the recruitment process and will select fellows on the criteria of their motivation, interests, degree, grades and experience. Applications (i.e. letter of intent, CVs and recommendation letters) will be collected by the Recruitment Committee and distributed to all participants. Short-listed candidates will be invited to visit the lab of the PI they are most interested in joining. Interviews during the visit will be carried out by teleconferencing to include at least one other participant of the Network as an interviewer. Problems with recruitment: If a partner cannot find an eligible candidate, acceptable applicants to other partners (not elected) may be offered the chance. If this is unsuccessful, the position will be re-announced with less specific requirements regarding disciplinary background. If no candidate for a position is found before month 12 of the project, that position will be cancelled, and crucial tasks will be done by staff at the host institution and other network trainees within the relevant WP.

  • International Course on Laboratory Animal Science

    The International Course on Laboratory Animal Science at BSRC A.FLEMING in Athens will be obligatory to those ESRs where an animal welfare course is not available locally. The programme duration is one week and is organized on an annual basis by the A.FLEMING (http://www.animalfacility.eu). The course includes a theoretical understanding on the needs, the limitations and the ethical issues in animal experimentation. A theoretical and practical course in statistics and management of an experiment involving animals will be programmed. A practical session involving animal handling will be included. The workshop will end with a written test and a certificate will be delivered to successful ESRs including appropriate ECTS grades.

  • Project Management course

    The project management course will cover planning, project management, creativity in research, group dynamics, networking, developing self-awareness and stress management. We will invite a representative from the International Project Management Association (IPMA-Nijkerk/Netherlands, http://ipma.ch) specialized in the management of publicly funded projects and the exploitation of results. This course will also include contributions from UD-GenoMed, Diagenode, Mosaiques, ACS, Exiqon, Yellow Research and SB Science Management and will be mandatory for all ESRs.

  • Workshop 1: “Folding chromatin in Three Dimensions”

    Location: Stockholm Organizer: Rolf Ohlsson Benefit to the ESRs and other trainees: This workshop will expose young researchers from all over Europe to a series of talks covering the current view we share for the three dimensional organization of the eukaryotic genome. New technologies employed worldwide and within the network (Chromosome conformation capture/3C-based) will be discussed. One speaker from SME will also cover different technology platforms (*H.Pendeville). Provisional Program Daniela Rhodes (Cambridge) Chromatin structure and recognition Wendy Bickmore (Edinburgh) Folding chromatin during development and disease Edith Heard (Paris) X-chromatin structure and dynamics during X inactivation Peter Fraser (Cambridge) Single molecule chromosome structure analysis Babis Spilianakis (Heraklion) Regulation of CD4 cell differentiation in three dimensions Peter Becker (Munich) Assembly of (hetero-)chromatin during early embryogenesis *Helene Pendeville (Liege) Automation of epigenetic assays Eran Segal (Rehovot) Nucleosome Disfavouring Sequences Alter Gene Expression

  • Open Lab Day

    Open Lab Days will be organized at which the ESRs invite the general public to the laboratories and present their research projects and results “hands on” to a general audience. Whenever possible, the open lab days will be synchronized and advertised together with the institutions’ “Open Doors” days organized by the different partner universities in order to maximize publicity and impact. Each ESR will be required to organize lab demonstrations and a short public lecture on her/his project.

  • Communication course

    Communication training will be based on lectures organized by the network on support and guidance of ESRs. Communication training includes training of writing skills, presentation and oral communication skills. Writing skills is usually addressed individually as part of each research project. The trainers will give practical advice on public speaking techniques and on how to deliver presentations to different target audiences or stakeholders. The ESRs will be able to apply their newly gained communication skills in scientific activities such as the summer schools.

  • Chromatin3D website

    Chromatin3D website. The website will provide comprehensive information about the science, technology and members of the network, its nodes and ongoing activities. It will include a popular science section featuring popular-science articles, blogs, interactive animations, and videos/podcasts of public lectures, many of which will be sourced from other outreach activities detailed below. Each ESR will be expected to take part in the development and maintenance of the website.

  • Chromatin3D Newsletter

    Annual Chromatin3D newsletter aimed at high-school and undergraduate university students as well as the wider public. All members of Chromatin3D (ESRs, PIs) will contribute to this format. The newsletter will popularize Chromatin3D’s activities by explaining its societal, technological and scientific impacts. It will include features about important scientific results and technical developments, interviews with ESRs and PIs about their work and career perspectives, as well as articles about Chromatin3D’s activities in general. The newsletter will appear in print and in electronic form to be distributed via the website and interested subscribers (schools, universities, individuals and companies).

  • Facebook Chromatin3D page

    Chromatin3D Facebook Group. Chromatin3D’s ESRs will set up an open Facebook group through which they can communicate among themselves and the general public. This social network complements the more technical internet-based transfer-of-knowledge and communication facilities on the Chromatin3D newsgroup as well as the network website. The Facebook group will feature personal sections for each ESR detailing their research projects, work environments as well as personal motivations, experiences and thoughts to serve as examples for the careers of upcoming young scientists. The group will be accessible to the public who will thus be enabled to engage online with Chromatin3D’s ESRs, e.g., by posting science-related questions, reading about the scientific progress, learning about other outreach activities, etc.

Publications

Coordinator

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS
Greece

EU contribution: EUR 969 547,68


N PLASTIRA STR 100
70013 HERAKLION
Greece
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Activity type: Research Organisations

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Participants

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

EU contribution: EUR 249 216,48


GESCHWISTER SCHOLL PLATZ 1
80539 MUENCHEN
Germany
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Activity type: Higher or Secondary Education Establishments

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BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Participation ended
Greece

EU contribution: EUR 0


FLEMING STREET 34
16672 VARI-ATHENS
Greece
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Activity type: Research Organisations

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FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Participation ended
Italy

EU contribution: EUR 258 061,32


VIA MOREGO 30
16163 GENOVA
Italy
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Activity type: Research Organisations

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THE UNIVERSITY OF EDINBURGH
United Kingdom

EU contribution: EUR 273 287,88


OLD COLLEGE, SOUTH BRIDGE
EH8 9YL EDINBURGH
United Kingdom
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Activity type: Higher or Secondary Education Establishments

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FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain

EU contribution: EUR 247 872,96


AVENIDA GRAN VIA HOSPITALET 199-203
08908 L'HOSPITALET DE LLOBREGAT
Spain
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Activity type: Research Organisations

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KAROLINSKA INSTITUTET
Sweden

EU contribution: EUR 527 318,64


Nobels Vag 5
17177 STOCKHOLM
Sweden
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Activity type: Higher or Secondary Education Establishments

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WEIZMANN INSTITUTE OF SCIENCE
Israel

EU contribution: EUR 260 300,52


HERZL STREET 234
7610001 REHOVOT
Israel
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Activity type: Higher or Secondary Education Establishments

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DIAGENODE
Belgium

EU contribution: EUR 250 560


RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE
4102 SERAING
Belgium
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT
Hungary

EU contribution: EUR 223 913,52


NAGYERDEI KRT 98
4032 DEBRECEN
Hungary
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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MOSAIQUES DIAGNOSTICS GMBH
Germany

EU contribution: EUR 249 216,48


ROTENBURGER STRASSE 20
30659 HANNOVER
Germany
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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AvantiCell Science Ltd
United Kingdom

EU contribution: EUR 273 287,88


GIBBSYARD BUILDING
KA6 5HW AYR
United Kingdom
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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Partner organisations

EXIQON AS
Denmark
BYGSTUBBEN 9
2950 VEDBAEK
Denmark
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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LIFEGLIMMER GMBH
Germany
MARKELSTRASSE 38
12163 BERLIN
Germany
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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YELLOW RESEARCH
Netherlands
HERENGRACHT 495
1017BT AMSTERDAM
Netherlands
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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SB SCIENCE MANAGEMENT UG
Germany
MUTHESIUSSTR 11
12163 BERLIN
Germany
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Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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