Skip to main content

Rapid Bioprocess Development

Objective

Reducing lead times of new medicinal drugs to the market by reducing process development and clinical testing timeframes is a critical driver in increasing European (bio)pharmaceutical industry competitiveness. Despite new therapeutic principles (e.g. the use of pluripotent stem cells, regenerative medicine and treatments based on personalised medicine or biosimilars) or regulatory initiatives to enable more efficient production, such as Quality by design (QbD) with associated Process Analytical Technology (PAT) tools , the slow progress in the development of new bioactive compounds still limits the availability of cheap and effective medicines. In addition, the competitiveness of European (bio)pharma industry is impacted by the unavailability of suitably trained personnel. Fundamental changes in the education of scientists have to be realised to address the need for changes in the traditional ‘big pharma’ business model and the focus on ‘translational medicine – more early stage clinical trials with patients, more external innovation and more collaboration’ . These changes in education should be based on combining cutting-edge science from the early stage of product development through to manufacturing with innovation and entrepreneurship as an integral part of the training. The Rapid Bioprocess Development ITN, employing 15 ESRs, brings together industrialist and academic experts with its main aim to address this critical need by developing an effective training framework in rapid development of novel bioactive molecules from the very early stages of potency and efficacy testing to the biomanufacturing process characterisation and effective monitoring. The main focus of the research is on oncology related proteins and recombinant proteins to be used in diabetes treatment, although the resulting monitoring and modelling methods will be applicable to other bioactive molecule process development as demonstrated by validation on a range of relevant bioactives.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/economics and business/business and management/business model
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /social sciences/economics and business
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /social sciences/economics and business/business and management/entrepreneurship
  • /medical and health sciences/clinical medicine/oncology

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 819 863,64

Participants (8)

ALCYOMICS LTD
United Kingdom
EU contribution
€ 273 287,88
Address
Bulman House Regent Centre
NE3 3 LS Newcastle Upon Tyne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RISE ACREO AB
Sweden
EU contribution
€ 527 318,64
Address
Box 1070
164 25 Kista
Activity type
Other
CHR. HANSEN A/S
Denmark
EU contribution
€ 290 081,88
Address
Boege Alle 10-12
2970 Hoersholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 580 163,76
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Belasis Avenue
TS23 1LH Billingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 527 318,64
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 249 216,48
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNISCHE UNIVERSITAT BERLIN
Germany
EU contribution
€ 498 432,96
Address
Strasse Des 17 Juni 135
10623 Berlin
Activity type
Higher or Secondary Education Establishments