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TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

Objective

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal.
TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).

Call for proposal

H2020-PHC-2014-single-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Address
Runderweg 6
8219 PH Lelystad
Netherlands
Activity type
Other
EU contribution
€ 2 473 986,45

Participants (45)

STATENS SERUM INSTITUT
Denmark
EU contribution
€ 1 586 952
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 957 480
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
ASTON UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 0
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE

Participation ended

Belgium
EU contribution
€ 0
Address
Rue Juliette Wytsman 14
1050 Bruxelles
Activity type
Research Organisations
SCIENSANO
Belgium
EU contribution
€ 111 864
Address
Juliette Wytsmanstraat 14
1050 Elsene
Activity type
Research Organisations
UNIVERSITEIT GENT
Belgium
EU contribution
€ 23 700
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
BANGOR UNIVERSITY
United Kingdom
EU contribution
€ 23 700
Address
College Road
LL57 2DG Bangor
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 604 824
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
INSTITUT PASTEUR
France
EU contribution
€ 528 980
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 714 513
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 951 792
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 0
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 0
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 220 030,80
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
YONSEI UNIVERSITY
South Korea
EU contribution
€ 0
Address
50 Yonsei Ro Seodaemun Gu
120 749 Seoul
Activity type
Higher or Secondary Education Establishments
STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER
Netherlands
EU contribution
€ 918 194,88
Address
Lange Kleiweg 161
2288 GJ Rijswijk Zh
Activity type
Research Organisations
Department of Health
United Kingdom
EU contribution
€ 1 416 150,84
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 0
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 415 224
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 0
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
EU contribution
€ 396 294,34
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
STELLENBOSCH UNIVERSITY
South Africa
EU contribution
€ 284 400
Address
Victoria Street Administration B Building
7600 Stellenbosch
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF CAPE TOWN
South Africa
EU contribution
€ 355 500
Address
Private Bag X3
7701 Rondebosch
Activity type
Higher or Secondary Education Establishments
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 1 194 647,50
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO
Italy
EU contribution
€ 118 500
Address
Via Del Vespro 129
90127 Palermo
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 308 100
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 936 937,93
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 218 040
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 218 040
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
THE UNIVERSITY OF SYDNEY
Australia
EU contribution
€ 0
Address
Camperdown Campus Arundel St 71/79
2006 Sydney
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 755 642,50
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL

Participation ended

Germany
EU contribution
€ 0
Address
Paul-ehrlich-strasse 51-59
63225 Langen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
United Kingdom
EU contribution
€ 252 686,56
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
KWAZULU NATAL RESEARCH INSTITUTE FOR TB-HIV (K-RITH) NPC
South Africa
EU contribution
€ 167 227,20
Address
719 Numbilo Road
4001 Durban
Activity type
Other
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 0
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 538 464
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 0
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 206 664
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
AERAS GLOBAL TB VACCINE FOUNDATION
United States
EU contribution
€ 0
Address
Research Boulevard 1405
20850 Rockville Md
Activity type
Research Organisations
INTERNATIONAL TUBERCULOSIS RESEARCH CENTER
South Korea
EU contribution
€ 0
Address
236 Gaposunhwan Ro Masanhappo Gu Chang Won Si
631 320 Gyeongsangnam Do
Activity type
Research Organisations
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
EU contribution
€ 0
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TRANSGENE SA
France
EU contribution
€ 0
Address
Boulevard Gonthier D Andernach - Parc D'innovation
67405 Illkirch-graffenstaden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT
Germany
EU contribution
€ 142 200
Address
Sudufer 10
17493 Greifswald-insel Riems
Activity type
Research Organisations
UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 159 264
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments