Objective
The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal.
TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
8219 PK Lelystad
Netherlands
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Participants (46)
2300 Kobenhavn S
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80539 Munchen
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Participation ended
B4 7ET Birmingham
1050 Elsene
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9000 Gent
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LL57 2DG Bangor
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89081 Ulm
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75724 Paris Cedex 15
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75794 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
31062 Toulouse Cedex 9
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50009 Zaragoza
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1211 Geneve
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8092 Zuerich
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4 Dublin
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120 749 Seoul
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2288 GJ Rijswijk Zh
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LS2 7UE Leeds
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8006 Zurich
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08916 Badalona Barcelona
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SN2 1FL Swindon
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7600 Stellenbosch
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7701 Rondebosch
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WC1E 7HT London
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90127 Palermo
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SW7 2AZ London
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2333 ZA Leiden
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1050 Bruxelles
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00149 Roma
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2006 Sydney
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OX1 2JD Oxford
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Participation ended
63225 Langen
SW1P 3JR London
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4001 Durban
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1011 Lausanne
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59019 Lille
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75654 Paris
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1015 Lausanne
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4051 Basel
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
4031 Basel
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00161 Roma
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20850 Rockville Md
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631 320 Gyeongsangnam Do
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1330 Rixensart
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67400 Illkirch-graffenstaden
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17493 Greifswald-insel Riems
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G1 1XQ Glasgow
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