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Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms  In T cells and neutrophils.

Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils.

Objective

We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population.
Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system.
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Coordinator

UNIVERSITY OF SURREY

Address

Stag Hill
Gu2 7xh Guildford

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 40 500

Participants (3)

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REDOXIS AB

Sweden

EU Contribution

€ 13 500

UNIVERSITATSKLINIKUM ERLANGEN

Germany

EU Contribution

€ 58 500

ASTON UNIVERSITY

United Kingdom

EU Contribution

€ 31 500

Project information

Grant agreement ID: 644035

Status

Ongoing project

  • Start date

    1 July 2015

  • End date

    30 June 2019

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 144 000

  • EU contribution

    € 144 000

Coordinated by:

UNIVERSITY OF SURREY

United Kingdom