Cel We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population.Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesnatural scienceschemical sciencesinorganic chemistryalkaline earth metalsmedical and health sciencesbasic medicineimmunologyautoimmune diseases Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Temat(-y) MSCA-RISE-2014 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Zaproszenie do składania wniosków H2020-MSCA-RISE-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Koordynator UNIVERSITY OF SURREY Wkład UE netto € 40 500,00 Adres Stag Hill GU2 7XH Guildford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Surrey, East and West Sussex West Surrey Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 40 500,00 Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko REDOXIS AB Szwecja Wkład UE netto € 13 500,00 Adres MEDICON VILLAGE SCHEELEVAGEN 2 223 81 Lund Zobacz na mapie MŚP Organizacja określiła się jako MŚP (firma z sektora małych i średnich przedsiębiorstw) w czasie podpisania umowy o grant. Tak Region Södra Sverige Sydsverige Skåne län Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 13 500,00 UNIVERSITATSKLINIKUM ERLANGEN Niemcy Wkład UE netto € 58 500,00 Adres MAXIMILIANSPLATZ 2 91054 Erlangen Zobacz na mapie Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 58 500,00 ASTON UNIVERSITY Zjednoczone Królestwo Wkład UE netto € 31 500,00 Adres ASTON TRIANGLE B4 7ET Birmingham Zobacz na mapie Region West Midlands (England) West Midlands Birmingham Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 31 500,00