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Miniaturized smart system for light stimulation and monitoring of wound healing

Objective

Chronic wounds represent a significant burden to patients, health care professionals, and health care systems, affecting over 40 million patients and creating costs of approximately 40 billion € annually. Goal of the project is the fabrication of a medical device for professional wound care. The device will use recently proven therapeutic effects of visible light to enhance the self-healing process and monitor the status and history of the wound during therapy. Light exposure in the red part of the spectrum (620-750nm) induces growth of keratinocytes and fibroblasts in deeper layers of the skin. The blue part of the spectrum (450–495nm) is known to have antibacterial effects predominantly at the surface layers of the skin. In order to be compliant with hygiene requirements the system will consist of two parts: 1. a disposable wound dressing with embedded optical waveguides and integrated sensors for the delivery of light and monitoring (temperature and blood oxygen) of the wound. 2. a soft and compliant electronic module for multiple use containing LEDs, a photodiode, a controller, analog data acquisition, a rechargeable battery, and a data transmission unit. Both parts of the device will be interconnected by a mechanically robust plug, enabling a low loss coupling of light into the waveguide structures and electrical interconnection to the sensors. The status of the wound will be monitored with temporal and low level spatial resolution. The electronic module will be optimized for functionality and user comfort, combining leading edge heterogeneous integration technologies (PCB embedding) and stretchable electronics approaches. The detailed effects of light-exposure schemes will be explored and backed by in-vitro and in-vivo animal studies. Results will be used to develop smart algorithms and implement it into respective programs and feedback loops of the device.

Call for proposal

H2020-ICT-2014-1
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Coordinator

TECHNISCHE UNIVERSITAT BERLIN
Address
Strasse Des 17 Juni 135
10623 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 587 500

Participants (7)

LABORATOIRES URGO

Participation ended

France
EU contribution
€ 96 159
Address
42 Rue De Longvic
21300 Chenove
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 401 218,75
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT
Switzerland
EU contribution
€ 0
Address
Rue Jaquet Droz 1
2000 Neuchatel
Activity type
Research Organisations
SIGNALGENERIX LIMITED
Cyprus
EU contribution
€ 324 375
Address
Grigori Afxentiou 23C Mesa Geitonia
4003 Limassol
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICROCHIP TECHNOLOGY CALDICOT LIMITED
United Kingdom
EU contribution
€ 410 000
Address
Phase 2 Castlegate Business Park
NP26 5YW Gwent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AMIRES SRO
Czechia
EU contribution
€ 151 750
Address
Stavitelska 1099/6
160 00 Praha 6
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
URGO RECHERCHE INNOVATION ET DEVELOPPEMENT
France
EU contribution
€ 504 308
Address
42 Rue De Longvic
21300 Chenove
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)