
PRISAR
Project ID: 644373Financé au titre de:
Preclinical Intra-Operative Image-Guided Surgery and Post-Operative Radiotherapy of Tumours
Détails concernant le projet
Coût total:
EUR 2 430 000Contribution de l'UE:
EUR 2 430 000Coordonné à/au(x)/en:
NetherlandsAppel à propositions:
H2020-MSCA-RISE-2014See other projects for this callRégime de financement:
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Objectif
The main objective and basic concept of our proposal is to improve intra-operative and post-operative targeted surgical probes and new detection systems for surgical intervention of cancer. The work revolves around the mobility of clinicians, scientists and technologists between twelve consortium partners and across four different countries. The goal is the implementation of inter-disciplinary, inter-sector, cross-training of personnel. As a consequence, this will serve to accelerate the development of improved imaging technologies and hybrid fluorescence/radionuclide probes for the surgical intervention of cancer. The hypothesis is that if we can develop a hybrid probe for both targeted image-guided surgery and post-operative molecular radiotherapy, we would be implementing a revolutionary imaging and therapeutic approach for oncology surgeons to help their patients by improving better overall survival and quality of life for the patient. There are four key objectives within this project: 1) synthesis of a near infra-red fluorescence (NIRF)-dye conjugated to a peptide that is targeted towards a tumour associated antigen, 2) deliver a novel clinical optoacoustic handheld camera to detect the fluorescence probe in deep tissue, 3) validate the probe/target combination across the subcellular, cellular, endoscopic and macroscopic levels with state-of-art technologies, and 4) develop the probe further by targeting a radionuclide entity to the fluorescent construct for postoperative radiotherapy. Surgeons would have a more definitive reference for resection, if the tumour margin can be clearly defined. If this can be achieved, the impact would be (a) reduced recurrence rates in patients by lowering the risk of residual tumour tissue remaining after surgery and as a consequence improve survival, (b) minimised removal of healthy tissues, c) reduced patient morbidity and hospital stay and d) significant health cost benefits.
Deliverables
Deliverables not available
Publications
-
Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer SurgeryAuthor(s): Marieke A. Stammes, Hendrica A. J. M. Prevoo, Meyke C. Ter Horst, Stéphanie A. Groot, Cornelis J. H. Van de Velde, Alan B. Chan, Lioe-Fee de Geus-Oei, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Elena B. Pasquale and Cornelis F. M. SierPublished in: Int. J. Mol. Sci, issue 2017, 18(2):307, 2017. Page(s) 307. ISSN: 1422-0067DOI: 10.3390/ijms18020307
-
Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis ImagingAuthor(s): Marieke A. Stammes, Vicky T. Knol-Blankevoort, Luis J. Cruz, Hans R. I. J. Feitsma, Laura Mezzanotte, Robert A. Cordfunke, Riccardo Sinisi, Elena A. Dubikovskaya, Azusa Maeda, Ralph S. DaCosta, Katja Bierau, Alan Chan, Eric L. Kaijzel, Thomas J. A. Snoeks, Ermond R. van Beek, Clemens W. G. M. LöwikPublished in: Molecular Imaging and Biology, 2016. ISSN: 1536-1632DOI: 10.1007/s11307-016-0972-7
-
Identification of cell-surface markers for detecting breast cancer cells in ovarian tissueAuthor(s): Inge T. A. Peters, Carina G. J. M. Hilders, Cornelis F. M. Sier, Alexander L. Vahrmeijer, Vincent T. H. B. M. Smit, J. Baptist Trimbos, Peter J. K. KuppenPublished in: Archives of Gynecology and Obstetrics, 2016. ISSN: 0932-0067DOI: 10.1007/s00404-016-4036-7
-
Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane ProteinsAuthor(s): Vahrmeijer, Alexander L.; Prevoo, Hendrica A.J.M; Hawinkels, Lukas J.A.C.; Kuppen, Peter J. K.; Boonstra, Martin C.; Cornelis F.M. Sier; de Geus, Susanna W L; van de Velde, Cornelis J.H.Published in: Biomarkers in Cancer, Vol 2016, Iss 8, Pp 119-133 (2016), issue 1, 2016. ISSN: 1179-299XDOI: 10.4137/BIC.S38542
-
The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell DeathAuthor(s): Marieke A. Stammes, Azusa Maeda, Jiachuan Bu, Deborah A. Scollard, Iris Kulbatski, Philip J. Medeiros, Riccardo Sinisi, Elena A. Dubikovskaya, Thomas J. A. Snoeks, Ermond R. van Beek, Alan B. Chan, Clemens W. G. M. Löwik, Ralph S. DaCostaPublished in: Frontiers in Oncology, issue 6, 2016. ISSN: 2234-943XDOI: 10.3389/fonc.2016.00221
-
Intraoperative Bildgebung von Pankreastumoren: Präklinische Validierung von Cetuximab konjugiert an Fluoreszenzfarbstoffe im Nahen Infrarotbereich im orthotopen Pankreastumor-MausmodellAuthor(s): M Saccomano, M Stammes, A Chan, F Alves, J NappPublished in: Zeitschrift für Gastroenterologie, issue 54/08, 2016. ISSN: 0044-2771DOI: 10.1055/s-0036-1587241
-
Preclinical uPAR-targeted multimodal imaging of locoregional oral cancerAuthor(s): M.C. Boonstra, P.B.A.A. Van Driel, S. Keereweer, H.A.J.M. Prevoo, M.A. Stammes, V.M. Baart, C.W.G.M. Löwik, A.P. Mazar, C.J.H. van de Velde, A.L. Vahrmeijer, C.F.M. SierPublished in: Oral Oncology, 2017. Page(s) 1-8. ISSN: 1368-8375DOI: 10.1016/j.oraloncology.2016.12.026
-
Comprehensive phantom for interventional fluorescence molecular imagingAuthor(s): Maria Anastasopoulou, Maximilian Koch, Dimitris Gorpas, Angelos Karlas, Uwe Klemm, Pilar Beatriz Garcia-Allende, Vasilis NtziachristosPublished in: Journal of Biomedical Optics, issue 21/9, 2016. Page(s) 91309. ISSN: 1083-3668DOI: 10.1117/1.JBO.21.9.091309
-
Preclinical evaluation of near-infrared (NIR) fluorescently labeled Cetuximab as a potential tool for fluorescence-guided surgeryAuthor(s): Mara Saccomano, Christian Dullin, Frauke Alves, Joanna NappPublished in: International Journal of Cancer, 2016. ISSN: 0020-7136DOI: 10.1002/ijc.30277
-
Automated ischemic lesion segmentation in MRI mouse brain data after transient middle cerebral artery occlusionAuthor(s): Inge A. Mulder, Artem Khmelinskii, Oleh Dzyubachyk, Sebastiaan de Jong, Nathalie Rieff, Marieke J. Wermer, Mathias Hoehn, Boudewijn Lelieveldt and Arn M. van den MaagdenbergPublished in: Frontiers in Neuroinformatics, issue 11:3, 2017. ISSN: 1662-453XDOI: 10.3389/fninf.2017.00003
-
Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imagingAuthor(s): Ivan Olefir, Elena Mercep, Neal C. Burton, Saak V. Ovsepian, Vasilis NtziachristosPublished in: Journal of Biomedical Optics, issue 21/8, 2016. Page(s) 86005. ISSN: 1083-3668DOI: 10.1117/1.JBO.21.8.086005
-
Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic SurgeryAuthor(s): Susanna W. L. de Geus, Leonora S. F. Boogerd, Rutger-Jan Swijnenburg, J. Sven D. Mieog, Willemieke S. F. J. Tummers, Hendrica A. J. M. Prevoo, Cornelis F. M. Sier, Hans Morreau, Bert A. Bonsing, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer, Peter J. K. KuppenPublished in: Molecular Imaging and Biology, 2016. Page(s) 1-13. ISSN: 1536-1632DOI: 10.1007/s11307-016-0959-4
-
Fluorescence- and multispectral optoacoustic imaging for an optimised detection of deeply located tumours in an orthotopic mouse model of pancreatic carcinomaAuthor(s): Joanna Napp, Marieke A. Stammes, Jing Claussen, Hendrica A.J.M. Prevoo, Cornelis F. M. Sier, Freek J. M. Hoeben, Marc S. Robillard, Alexander L. Vahrmeijer, Tim Devling, Alan B. Chan, Lioe-Fee de Geus-Oei, Frauke AlvesPublished in: International Journal of Cancer, 2017. ISSN: 0020-7136DOI: 10.1002/ijc.31236
-
Data-driven identification of prognostic tumor subpopulations using spatially mapped t-SNE of mass spectrometry imaging dataAuthor(s): Walid M. Abdelmoula, Benjamin Balluff, Sonja Englert, Jouke Dijkstra, Marcel J. T. Reinders, Axel Walch, Liam A. McDonnell, Boudewijn P. F. LelieveldtPublished in: Proceedings of the National Academy of Sciences, issue 113/43, 2016. Page(s) 12244-12249. ISSN: 0027-8424DOI: 10.1073/pnas.1510227113
-
Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic ApproachesAuthor(s): Eric L. Kaijzel, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. Löwik, Luis J. Cruz.Published in: Current Pharmaceutical Design, issue 23, 2017. ISSN: 1381-6128DOI: 10.2174/1381612823666170116141116
-
EpCAM as multi-tumour target for near-infrared fluorescence guided surgeryAuthor(s): Löwik, Clemens; Fish, A.; Lelieveldt, Boudewijn; Dijkstra, Jouke; Cordfunke, R. A.; Tummers, Q.R.J.G.; Driel, Pieter; Vahrmeijer, A. L.; Snoeks, thomas; Velde, Cornelis; Boonstra, M.; Kuppen, P J K; Keereweer, Stijn; Van de Giessen, Martijn; Prevoo, H.A.J.M.; Sier, Cornelis; van Eendenburg, J. D. H.Published in: B M C Cancer, 16(1), issue 1, 2016. ISSN: 1471-2407DOI: 10.1186/s12885-016-2932-7
-
Stromal cells as target for image-guided surgery of breast cancer.Author(s): Sier CF, Bhairosing S, Prevoo HA, van Vlierberghe RL, Hawinkels LJ, Mesker WE, Van de Velde CJ, Kuppen PJ, Vahrmeijer ALPublished in: Cancer Microenvironment, issue 8 Suppl. 1, 2015. Page(s) 130-131.DOI: 10.1007/s12307-015-0175-9
Open Access
Open Access
Coordinateur
Contribution de l'UE: EUR 378 000
PLESMANLAAN 1
2333 BZ LEIDEN
Netherlands
Participants
Contribution de l'UE: EUR 486 000
ALBINUSDREEF 2
2333 ZA LEIDEN
Netherlands
Contribution de l'UE: EUR 243 000
Robert-Koch-Strasse 40
37075 GOETTINGEN
Germany
Contribution de l'UE: EUR 162 000
Minderbroedersberg 4-6
6200 MAASTRICHT
Netherlands
Contribution de l'UE: EUR 54 000
INGOLSTADTER LANDSTRASSE 1
85764 NEUHERBERG
Germany
Contribution de l'UE: EUR 108 000
Vondellaan 11
5611 NX Eindhoven
Netherlands
Contribution de l'UE: EUR 216 000
WINTON HOUSE WINTON SQUARE
RG21 8EN BASINGSTOKE
United Kingdom
Contribution de l'UE: EUR 189 000
Arcisstrasse 21
80333 MUENCHEN
Germany
Contribution de l'UE: EUR 108 000
10 rue d'Enghien
75010 PARIS
France
Contribution de l'UE: EUR 162 000
The Coliseum Riverside Way, Watchmoor Park
GU15 3YL Camberley
United Kingdom
Contribution de l'UE: EUR 54 000
Leenmanslag 57
2805 HT Gouda
Netherlands
Contribution de l'UE: EUR 108 000
HABICHTSTRASSE 21
84036 LANDSHUT
Germany
Contribution de l'UE: EUR 54 000
S GRAVENDIJKWAL 230
3015 CE ROTTERDAM
Netherlands
Contribution de l'UE: EUR 108 000
HOFGARTENSTRASSE 8
80539 MUENCHEN
Germany
Dernière mise à jour le: 2017-07-31
Numéro d'enregistrement: 194198
Dernière mise à jour le 2017-07-31Share this page