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Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics

Objective

Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.

Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.

The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will:
•Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package
•Integrate the subsystems and build a multi-array laser interferometer system
•Develop a process flow scalable to high volumes for all sub-systems and their integration steps
•Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events
•Validate the system in a clinical setting

Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).

The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.

Call for proposal

H2020-ICT-2014

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Sub call

H2020-ICT-2014-1

Coordinator

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Net EU contribution
€ 721 413,00
Address
Kapeldreef 75
3001 Leuven
Belgium

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Research Organisations
Other funding
€ 721 413,00

Participants (8)

MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Netherlands
Net EU contribution
€ 602 990,00
Address
Endepolsdomein 5
6229GW Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 602 990,00
SIOS MESSTECHNIK
Germany
Net EU contribution
€ 662 750,00
Address
Am Vogelherd 46
98693 Ilmenau

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Thüringen Thüringen Ilm-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 662 750,00
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Net EU contribution
€ 426 579,00
Address
Western Road
T12 YN60 Cork

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 426 579,00
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 399 500,00
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Other funding
€ 399 500,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 215 000,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 215 000,00
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 274 059,00
Address
327 Mile End Road
E1 4NS London

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Other funding
€ 274 059,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 176 915,00
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Other funding
€ 176 915,00
FUNDICO BVBA
Belgium
Net EU contribution
€ 150 000,00
Address
Gruuthuselaan 19
8020 Oostkamp

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. West-Vlaanderen Arr. Brugge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 150 000,00