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Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Objective

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.
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Coordinator

UNIVERSITA DEGLI STUDI DI CAMERINO

Address

Piazza Cavour 19f
62032 Camerino

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 81 000

Participants (5)

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THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 22 500

BIOMOLECULAR RESEARCH GENOMICS SRL

Italy

EU Contribution

€ 45 000

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Italy

EU Contribution

€ 58 500

EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS

Turkey

EU Contribution

€ 130 500

ELVESYS SAS

France

Partners (1)

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COMSATS INSTITUTE OF INFORMATION TECHNOLOGY

Project information

Grant agreement ID: 645693

Status

Closed project

  • Start date

    1 December 2014

  • End date

    30 November 2018

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 337 500

  • EU contribution

    € 337 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI CAMERINO

Italy