Objective The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2014 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Call for proposal H2020-MSCA-RISE-2014 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITA DEGLI STUDI DI CAMERINO Net EU contribution € 81 000,00 Address PIAZZA CAVOUR 19F 62032 Camerino Italy See on map Region Centro (IT) Marche Macerata Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 81 000,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 22 500,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 22 500,00 BIOMOLECULAR RESEARCH GENOMICS SRL Italy Net EU contribution € 45 000,00 Address VIA REDIPUGLIA 21A 35131 PADOVA See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Veneto Padova Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 45 000,00 UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Italy Net EU contribution € 58 500,00 Address PIAZZA DELL'ATENEO NUOVO 1 20126 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 58 500,00 EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS Türkiye Net EU contribution € 130 500,00 Address Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4A Kulucka Merkezi, Pendik 34906 Istanbul See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region İstanbul İstanbul İstanbul Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 130 500,00 ELVESYS France Net EU contribution € 0,00 Address 172 RUE DE CHARONNE B2 2 EME ETAGE 75011 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. COMSATS UNIVERSITY ISLAMABAD Pakistan Net EU contribution € 0,00 Address Park Road, Chak Shahzad 44000 Islamabad See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data