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Monitor population immunity against vaccine preventable diseases

Objective

In the recent years an unprecedented effort has been made to increase the rates of childhood immunization in resource poor countries. This has translated into an increased number of children receiving vaccines and a parallel decrease in the rate of illnesses from vaccine preventable diseases. However, in some regions it has proven difficult to achieve optimal levels of immunization mainly because of issues concerning communication, management and poor utilization of resources. Recent studies have questioned the validity of available vaccine coverage data and the way they are collected. Currently, both the progress of the vaccination programs and indirectly the level of protection in a population are inferred on the basis of administrative records. This largely unverified information is also utilized as performance indicator to allocate funds from government and donor agencies. Such self-certification practice does not incentivize the optimization of resources while it has been increasingly questioned in terms of its validity and integrity. We propose to develop and validate an innovative technical solution based on an assay system that integrates multiplex capability and analytical performance, to simultaneously quantify antibody levels against the major vaccine components, with both automation and wireless connectivity to produce spatial-temporal co-ordinates of individual determinations. The multiplex capability will facilitate the analysis of cross coverage monitoring while generating reactivity profiles against the different vaccine components to discriminate vaccinated versus infected individuals. Spatial temporal co-ordinates of assay results will be used to generate interactive data sets for modeling changes in the age-specific risk of infection and the risk of outbreaks. The proposed system represents a formidable tool of unprecedented power to monitor the progress of different vaccination programs and experimentally validate record-based coverage data. The consortium proposes to develop an additional implementation of the technology, a low-cost portable microarray solution for healthcare point of testing (i.e. private doctors or pediatrician clinics, small district hospitals, rapid control of real vaccination profile in emergency situations) that converts the protein microarray for the determination of antibody protection against vaccines antigens into a lateral flow protein microarray, which can be coupled with software application for Smart phones to read the results.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-MSCA-RISE-2014
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 328 500

Participants (5)

POLO D'INNOVAZIONE DI GENOMICA, GENETICA E BIOLOGIA SCARL
Italy
EU contribution
€ 297 000
Address
Via Fiorentina 1
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 90 000
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 117 000
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
MICROTEST MATRICES LTD

Participation ended

United Kingdom
EU contribution
€ 0
Address
Exhibition Road, Bessemer Building
SW7 2AZ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENIALIS D.O.O
Slovenia
EU contribution
€ 220 500
Address
Koprska Ulica 72
1000 Ljubljana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

MINISTERE DE LA SANTE
Burkina Faso
Address
03 Bp 7009
7003 Ouagadougou
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)