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Multimodal imaging of the in vivo fate of bone transplants

Objective

The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration.
The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies.
A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

H2020-MSCA-RISE-2014
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Greece
Activity type
Research Organisations
EU contribution
€ 72 000

Participants (7)

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 18 000
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITE DE MONS
Belgium
EU contribution
€ 18 000
Address
Place Du Parc 20
7000 Mons
Activity type
Higher or Secondary Education Establishments
BONUS THERAPEUTIC LTD
Israel
EU contribution
€ 0
Address
8 A Bldg Matam Advanced Technology Park
3508408 Haifa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOIMAG SOLUCIONES DE CONTRASTE SL
Spain
EU contribution
€ 103 500
Address
Carretera N 521 Km 41,800
10071 Caceres
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
EU contribution
€ 135 000
Address
Alexandras Avenue 116
114 72 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 67 500
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 58 500
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations