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Multimodal imaging of the in vivo fate of bone transplants

Multimodal imaging of the in vivo fate of bone transplants

Objective

The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration.
The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies.
A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.
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Coordinator

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Address

End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi

Greece

Activity type

Research Organisations

EU Contribution

€ 72 000

Participants (7)

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AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 18 000

UNIVERSITE DE MONS

Belgium

EU Contribution

€ 18 000

BONUS THERAPEUTIC LTD

Israel

BIOIMAG SOLUCIONES DE CONTRASTE SL

Spain

EU Contribution

€ 103 500

BIOEMISSION TECHNOLOGY SOLUTIONS IKE

Greece

EU Contribution

€ 135 000

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 67 500

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 58 500

Project information

Grant agreement ID: 645757

Status

Closed project

  • Start date

    1 June 2015

  • End date

    31 May 2019

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 472 500

  • EU contribution

    € 472 500

Coordinated by:

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Greece