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Development of a non-invassive breath test for early diagnosis of tropical diseases

Objective

This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hydatidosis, Leishmaniasis and Dengue) from different geographical locations (Europe, South America and Maghreb). Breath sampling will follow a standardised procedure. Analytical chemistry methods will be employed for the identification of the breath volatile biomarkers of these diseases. A pool of potential nanomaterials with high affinity towards the identified VOCs will be selected (e.g. gold nanoparticles, carbon nanotubes and semiconducting nanowires, either pristine or functionalised with selected hydrophobic organic molecules and/or bio-molecules). For maximising the possibility of success of our methodology, we will investigate the synergic effect of different advanced and complementary chemical sensing techniques: Mid-Infrared Quantum Cascade Laser spectroscopy and different types of Chemical Gas Sensors devices. These techniques are particularly attractive, since they can be miniaturised and are suitable for building on-site portable systems. Advanced pattern recognition algorithms will be employed for building discriminative models for the identification of the fingerprints of the different tropical diseases studied, and multisensors data fusion will be then applied for obtaining enhanced resulyts. A point of care prototype will be proposed on the basis of the results obtained and validated on-site.

Call for proposal

H2020-MSCA-RISE-2014
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Coordinator

UPPSALA UNIVERSITET
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 18 000

Participants (10)

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Participation ended

Israel
EU contribution
€ 4 500
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU METALE NEFEROASE SIRARE-IMNR
Romania
EU contribution
€ 184 500
Address
Bulevardul Biruintei 102
077145 Pantelimon Ilfov

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Activity type
Research Organisations
POLITECHNIKA GDANSKA
Poland
EU contribution
€ 126 000
Address
Ul. Gabriela Narutowicza 11/12
80-233 Gdansk

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Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 198 000
Address
Helmholtzstrasse 16
89081 Ulm

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Activity type
Higher or Secondary Education Establishments
MOLECULAR FINGERPRINT SWEDEN AB
Sweden
EU contribution
€ 67 500
Address
Eksatravagen 130
756 55 Uppsala

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SITEX 45 SRL
Romania
EU contribution
€ 202 500
Address
Ghica Tei Blvd,bl.40,ap.2 Dept.2 114
023709 Bucharest

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JLM INNOVATION GMBH
Germany
EU contribution
€ 121 500
Address
Beethovenweg 41
72076 Tuebingen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIWERSYTECKIE CENTRUM MEDYCYNY MORSKIEJ I TROPIKALNEJ
Poland
EU contribution
€ 63 000
Address
Ul Powstania Styczniowego 9 B
81519 Gdynia

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Activity type
Other
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 315 000
Address
Carrer De Escorxador
43003 Tarragona

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Activity type
Higher or Secondary Education Establishments
INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI
Romania
EU contribution
€ 85 500
Address
Aleea Grigore Ghica Voda 41A
700487 Iasi

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Activity type
Research Organisations

Partners (3)

INSTITUT PASTEUR DE TUNIS
Tunisia
Address
Place Pasteur 13
1002 Tunis

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Activity type
Research Organisations
UNIVERSITE MOULAY ISMAIL
Morocco
Address
Marjane Ii
50 000 Meknes

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Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE PAMPLONA
Colombia
Address
Ciudad Universitaria Km 1 Via Bucaramanga
Pamplona

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Activity type
Higher or Secondary Education Establishments