Skip to main content

The Development of Medium- and Large-Scale Sustainable Manufacturing Process Platforms for Clinically Compliant Solid Core Nanopharmaceuticals

Objective

A number of nanomedicine formulations have enabled, or been shown to hold considerable potential for enabling more effective and less toxic therapeutic interventions. However, progress to date in translating these initiatives to commercial success has been limited. One of the main reasons for this bottleneck is due to the inability of researchers and stakeholders to manufacture batches of the nanomedicine product at the required scale and according to Good Manufacturing Practice (GMP) requirements. The NANOFACTURING project will focus on
- facilitating access to required infrastructures and expertise
- creating GMP pilot lines for up-scaling manufacturing
- addressing the current developmental and production gaps
- taking nanomaterials already successfully produced at proof-of-concept/milligram levels and facilitating their scale-up to sub-kilogram quantities
- providing large-scale and GMP production for clinical trials and nanomedicine translation.
The NANOFACTURING project, through a consortium of 9 partners, will develop the synthetic processes, process control methods, analytical assays for QA/QC, functional specifications, and best practices, interfacing existing R&D centres of excellence, transfer organisations and private GMP manufacturing facilities (including SMEs) to ensure efficient translation from discovery through to first in man, proof-of-concept studies and beyond to Phase III according to industrial and regulatory standards. Specifically, the NANOFACTURING project aims to create a platform process for early, mid- and large-scale manufacturing of glycan-coated gold nanoparticles (GNPs), a widely researched and developed class of self-forming nanoparticles. The ability to engineer new nanopharmaceuticals based on this patent protected platform technology, developed by Midatech Biogune S.L. (Project Coordinator), will have inherent advantages over existing treatments for multiple therapeutic areas.

Call for proposal

H2020-NMP-2014-2015

See other projects for this call

Sub call

H2020-NMP-PILOTS-2014

Coordinator

MIDATECH PHARMA ESPANA SL
Net EU contribution
€ 2 516 593,75
Address
Parque Tecnologico De Bizkaia Edificio 800 2a Planta
48160 Derio
Spain

See on map

Region
Noreste País Vasco Bizkaia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (9)

CENTRE FOR PROCESS INNOVATION LIMITED LBG
United Kingdom
Net EU contribution
€ 2 080 420,50
Address
Wilton Centre Wilton
TS10 4RF Redcar Cleveland

See on map

Region
North East (England) Tees Valley and Durham South Teesside
Activity type
Research Organisations
Other funding
€ 0,00
PROCHIMIA SURFACES SP. Z O.O.
Poland
Net EU contribution
€ 472 875,00
Address
Zacisze 2
81823 Sopot

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Makroregion północny Pomorskie Trójmiejski
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
GALCHIMIA SA
Spain
Net EU contribution
€ 675 553,75
Address
Parque Empresarial De Touro Parcela 26-27 Fonte Diaz
15822 Touro A Coruna

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Galicia A Coruña
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
MIDATECH LTD
United Kingdom
Net EU contribution
€ 866 958,75
Address
Oddfellows House 19 Newport Road
CF24 0AA Cardiff

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 416 613,02
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 612 921,00
Address
Belfield
4 Dublin

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25
LGAI TECHNOLOGICAL CENTER SA
Spain
Net EU contribution
€ 409 708,75
Address
Ronda De La Font Del Carme Sn Bellaterra Campus De La Universitat Autonoma De Barcelona
08193 Cerdanyola Del Valles Barcelona

See on map

Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS

Participation ended

Italy
Net EU contribution
€ 76 618,41
Address
Via Adamello 16
20139 Milano
Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Other funding
€ 0,00
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 0,00
Address
Batiment Ce 3316 Station 1
1015 Lausanne

See on map

Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
€ 443 125,00
"INSTITUTO TUMORI ""GIOVANNI PAOLO II"""
Italy
Net EU contribution
€ 187 131,59
Address
Via Orazio Flacco 65
70126 Bari

See on map

Region
Sud Puglia Bari
Activity type
Research Organisations
Other funding
€ 0,00