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PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data

PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data

Objective

In the coming decade a significant number of the 500.000.000 European (EU/EEA) citizens will have their genome determined routinely. This will be complemented with much cheaper (currently ~20 Euro per measurement) acquisition of the metabolome of biofluids (e.g. urine, saliva, blood plasma) which will link the genotype with metabolome data that captures the highly dynamic phenome and exposome of patients. Having such low cost solutions will enable, for the first time, the development of a truly personalised and evidence-based medicine founded on hard scientific measurements. The exposome includes the metabolic information resulting from all the external influences on the human organism such as age, behavioural factors like exercise and nutrition or other environmental factors.
Considering that the amount of data generated by molecular phenotyping exceeds the data volume of personal genomes by at least an order of magnitude, the collection of such information will pose dramatic demands on biomedical data management and compute capabilities in Europe. For example, a single typical National Phenome Centre, managing only around 100,000 human samples per year, can generate more than 2 Petabytes of data during this period alone. A scale-up to sizable portions of the European population over time will require data analysis services capable to work on exabyte-scale amounts of biomedical phenotyping data, for which no viable solution exists at the moment.
The PhenoMeNal project will develop and deploy an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic.

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Address

Meyerhofstrasse 1
69117 Heidelberg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 848 460,59

Participants (13)

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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 1 232 095

LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE

Germany

EU Contribution

€ 632 500

UNIVERSITAT DE BARCELONA

Spain

EU Contribution

€ 365 937,50

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 280 376,25

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE

Italy

EU Contribution

€ 225 750

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 528 930

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 777 761,25

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 916 655

BIOBANKS AND BIOMOLECULAR RESOURCESRESEARCH INFRASTRUCTURE CONSORTIUM(BBMRI-ERIC)

Austria

EU Contribution

€ 15 875

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 379 749,75

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

EU Contribution

€ 276 833,75

SIB INSTITUT SUISSE DE BIOINFORMATIQUE

Switzerland

CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA SOCIETÀ A RESPONSABILITÀ LIMITATA

Italy

EU Contribution

€ 203 995,66

Project information

Grant agreement ID: 654241

Status

Closed project

  • Start date

    1 September 2015

  • End date

    31 August 2018

Funded under:

H2020-EU.1.4.1.3.

  • Overall budget:

    € 8 005 909,75

  • EU contribution

    € 7 684 919,75

Coordinated by:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany