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PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data

Objective

In the coming decade a significant number of the 500.000.000 European (EU/EEA) citizens will have their genome determined routinely. This will be complemented with much cheaper (currently ~20 Euro per measurement) acquisition of the metabolome of biofluids (e.g. urine, saliva, blood plasma) which will link the genotype with metabolome data that captures the highly dynamic phenome and exposome of patients. Having such low cost solutions will enable, for the first time, the development of a truly personalised and evidence-based medicine founded on hard scientific measurements. The exposome includes the metabolic information resulting from all the external influences on the human organism such as age, behavioural factors like exercise and nutrition or other environmental factors.
Considering that the amount of data generated by molecular phenotyping exceeds the data volume of personal genomes by at least an order of magnitude, the collection of such information will pose dramatic demands on biomedical data management and compute capabilities in Europe. For example, a single typical National Phenome Centre, managing only around 100,000 human samples per year, can generate more than 2 Petabytes of data during this period alone. A scale-up to sizable portions of the European population over time will require data analysis services capable to work on exabyte-scale amounts of biomedical phenotyping data, for which no viable solution exists at the moment.
The PhenoMeNal project will develop and deploy an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic.

Call for proposal

H2020-EINFRA-2014-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 848 460,59

Participants (13)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 232 095
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE
Germany
EU contribution
€ 632 500
Address
Weinberg 3
06120 Halle
Activity type
Research Organisations
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 365 937,50
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 280 376,25
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE
Italy
EU contribution
€ 225 750
Address
Piazza San Marco 4
50121 Firenze
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 528 930
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 777 761,25
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 916 655
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)
Austria
EU contribution
€ 15 875
Address
Neue Stiftingtalstrasse 2/B/6
8010 Graz
Activity type
Research Organisations
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 379 749,75
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 276 833,75
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 0
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA SOCIETÀ A RESPONSABILITÀ LIMITATA
Italy
EU contribution
€ 203 995,66
Address
Localita Piscina Manna Edificio 1
09050 Pula Cagliari
Activity type
Research Organisations