Obiettivo One of the most intriguing, yet controversial findings in neuroscience in the past two decades is the discovery of the mirror neuron system (MNS). These visuo-motor neurons discharge both when a monkey does a particular goal-directed action and also when it observes another individual doing a similar action. The result of this mechanism is thought to be the capacity to recognize that an individual is performing an action, to differentiate this action from others analogous to it, and to use this information in order to act appropriately. This mechanism has been proposed as the basis for social cognition, and deficits in social understanding, such as those seen in autism spectrum disorder, have been linked to deficits in the MNS. Here I propose to use 2 novel approaches to address the neurobiological and behavioral significance of the human mirror neuron system (hMNS). (a) I will use Electrocorticography (ECoG) in neurosurgical patients to assess where, when, and how neurons in the prefrontal, parietal and sensorimotor regions are involved in action recognition. (b) I will employ scalp EEG and behavioral measures in a unique cohort of patients with damage centered in the Inferior Frontal Gyrus (IFG) or the Inferior Parietal Lobule (IPL). If the IFG and IPL are the core regions of the hMNS, patients with lesions to these regions should show deficits in understanding others’ actions, intentions and emotions (when these are expressed by body motion). This research will further our knowledge on the neural underpinnings of social understanding, and on the consequences of deficits in these neural networks. Campo scientifico medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologystrokemedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Parole chiave mirror neurons motor simulation understanding others embodied cognition EEG lesion patients ECoG Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinatore THE HEBREW UNIVERSITY OF JERUSALEM Contribution nette de l'UE € 263 385,00 Indirizzo EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Israele Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 263 385,00 Partner (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto Partner Le organizzazioni partner contribuiscono all’attuazione dell’azione, ma non sottoscrivono l’accordo di sovvenzione. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Stati Uniti Contribution nette de l'UE € 0,00 Indirizzo FRANKLIN STREET 1111 12 FLOOR 94607 OAKLAND CA Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 172 130,40
