Obiettivo Resistance (R) loci with nucleotide binding/leucine rich repeat (NB-LRR or NLR) domains have been identified as the major causal genes for hybrid necrosis, which presents an extreme example of the trade-off between plant growth and the activation of immune system. This is an exciting finding both for plant breeders and plant pathologists. However, how these NLR proteins or even the whole NLR family lead to hybrid necrosis, how they contribute to fitness under natural conditions, and how this is reflected in their extreme sequence variation remain largely unknown. In this proposal, I plan to exhaustively explore their function by systematically knocking out the NLR loci from genome of different Arabidopsis accessions using genome editing, and testing their fitness performance in the natural habitat. I will also reveal the cellular and biochemical mechanisms by which NLR proteins inappropriately interact with other cellular proteins to cause hybrid necrosis and compare the hybrid necrosis activity with pathogen induced immunity. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesbiological sciencesgeneticsgenomes Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Contribution nette de l'UE € 159 460,80 Indirizzo HOFGARTENSTRASSE 8 80539 Munchen Germania Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 159 460,80