Objectif The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking. In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking. This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective. Champ scientifique natural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencesphysical sciencesthermodynamicsmedical and health sciencesbasic medicinephysiologysocial scienceslawnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2014 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-RI - RI – Reintegration panel Coordinateur STICHTING VU Contribution nette de l'UE € 177 598,80 Adresse DE BOELELAAN 1105 1081 HV Amsterdam Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 177 598,80