Cel Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape specificity in connectivity and it is highly elusive what promotes variability in synaptic connectivity and whether this is behaviourally relevant. To work on these questions I have chosen the Drosophila olfactory system, which is well-defined both on the levels of circuitry and behaviour and as such well-suited to answer these question. Furthermore, from the perspective of circuitry, it is particularly appropriate as it is comprised of both deterministic and non-deterministic synaptic connectivity. In a first step to tackle the question, I will perform a screen to identify genes shaping deterministic and non-deterministic neural connectivity. In parallel, I will investigate olfactory behavioural variability in the fly and correlate this to circuitry variations on the morphological, synaptic and electrophysiological level. After identifying genes that are important for connectivity and correlating circuit to behavioural variability, I aim to modify circuit variability to alter behaviour. Dziedzina nauki natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencescell biologycell signalingnatural sciencescomputer and information sciencesartificial intelligencecomputer visionnatural sciencesbiological sciencesgeneticsmutationmedical and health scienceshealth sciencespersonalized medicine Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator FREIE UNIVERSITAET BERLIN Wkład UE netto € 142 884,00 Adres KAISERSWERTHER STRASSE 16-18 14195 Berlin Niemcy Zobacz na mapie Region Berlin Berlin Berlin Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 142 884,00 Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko VIB VZW Zakończenie uczestnictwa Belgia Wkład UE netto € 28 800,00 Adres SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT Zobacz na mapie Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 28 800,00
