Obiettivo The main goal of this IF research proposal is to produce novel nanoparticle-based multimodal contrast agents for their use in breast cancer diagnosis by combining Magnetic Resonance Imaging, Digital Mammography, X-ray Computed Tomography and Ultrasonography. In doing so, we will develop a new high-productivity strategy to synthesize multimodal hybrid nanoparticles, which consists in femtosecond-laser-induced-ablation of a metal plate immersed into a solvent containing chemicals, in combination with direct nanosecond-laser photolysis in solution of these chemicals. This research will be coupled to an in situ study of the high-productivity laser fabrication process and the analysis of the underlying mechanisms which allows the nucleation and growth of these hybrid nanoparticles. Moreover, we will analyze the structure, composition, physical and colloidal properties of the as-synthesized hybrid nanoparticles, as well as the in vitro performance of these nanoparticles as contrast agents in Magnetic Resonance Imaging, Ultrasonography and X-ray imaging techniques. We will also evaluate the citotoxicity of the as synthesized hybrid nanoparticles in normal cells and tumor breast cells lines. Finally, we will target these nanoparticles toward the human epidermal growth factor receptor 2 (HER2) which is overexpressed in breast cancers with a poor prognosis and higher disease recurrence, and we will evaluated in vitro the targeting ability of the obtained anti-HER2-nanoparticles conjugates for HER2+ breast cancer cells. Campo scientifico medical and health sciencesclinical medicineoncologybreast cancerengineering and technologymaterials engineeringcoating and filmsengineering and technologynanotechnologynano-materialsengineering and technologymaterials engineeringceramicsnatural sciencesphysical sciencesopticslaser physics Parole chiave ultra-short pulse laser ablation in liquids laser solution photolysis synthesis of multimodal nanoparticles colloidal dispersions MRI Ultrasonography Digital Mammography X-ray CT Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinatore UNIVERSITAT WIEN Contribution nette de l'UE € 166 156,80 Indirizzo UNIVERSITATSRING 1 1010 Wien Austria Mostra sulla mappa Regione Ostösterreich Wien Wien Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 166 156,80