CORDIS
EU research results

CORDIS

English EN
Mechanical regulation of tissue growth and signalling

Mechanical regulation of tissue growth and signalling

Objective

The control of tissue size and morphology is a fundamental problem that is remarkably ill understood. Although extensive research has focussed on the genetic and biochemical control of tissue growth, significantly less attention has been paid to the mechanical aspect of growth regulation, even though ample evidence indicates that any deformation or shape change is, to some degree, a result of force acting on a mass. Unravelling the basis of the mechanical-biochemical co-regulation in tissue growth control will not only increase our understanding of organismal development but also potentially represent a novel therapeutic target in growth-related diseases such as cancer. With this in mind, I aim to address two central questions:
1) How do mechanical stresses generated by growing tissues impact signalling networks to modulate tissue growth and morphology?
2) What is the function of in situ mechanical force on normal tissue growth and 3D architecture?
Using the Drosophila wing disc as the model tissue, I will employ a combinatorial biophysical, molecular, genetic and computational modelling approach to address the proposed questions. With a novel tissue stretching and compression device, I will initially identify key signalling events mediating the growth responses downstream of mechanical force. In parallel, by individually altering the genetic or the mechanical properties of the system, I will address co-regulation between mechanics and tissue growth. My research will lay the foundations for our understanding of tissue growth control by mechanical forces - a finding that may ultimately help to design novel treatment strategies for cancer. The classical approach to restrain cell growth involves targeting of the underlying genetic defect; however it might be more advantageous to apply physical therapy instead in situations where biochemical treatments do not suffice.

Coordinator

UNIVERSITY COLLEGE LONDON

Address

Gower Street
Wc1e 6bt London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 195 454,80

Project information

Grant agreement ID: 657088

Status

Grant agreement terminated

  • Start date

    1 January 2016

  • End date

    31 December 2017

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 195 454,80

  • EU contribution

    € 195 454,80

Coordinated by:

UNIVERSITY COLLEGE LONDON

United Kingdom