Investigating embryonic development at the time of implantation using embryos and ES cells

Projektinformationen

embryonic rosettes

ID Finanzhilfevereinbarung: 657995

DOI 10.3030/657995

Abgeschlossenes Projekt

EK-Unterschriftsdatum 9 März 2015

Startdatum 1 Februar 2016

Enddatum 31 Januar 2018

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 183 454,80

EU-Beitrag € 183 454,80

Koordiniert durch

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Ziel

The mouse embryo is an excellent model for human development. Its preimplantation stages of development in vitro have been extensively studied. Now similar approaches can be applied to implantation stages, previously hidden from view in the uterus. It was recently revealed that formation of a rosette structure by pluripotent epiblast cells can be recapitulated by ES cells cultured in extracellular matrix proteins. I will determine the extent to which such rosettes can undertake autonomous development or if they require flanking extraembryonic tissues. I will characterise the patterns of the normal development of these tissues from the point of implantation to the time of gastrulation. I will determine the extent to which explants of extraembryonic tissues can influence the development of rosettes of epiblast cells. Altogether, these experiments will expand our knowledge of embryonic development and how to manipulate the developmental potential of pluripotent cells.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › cell biology
• natural sciences › biological sciences › developmental biology
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › obstetrics
• medical and health sciences › clinical medicine › embryology

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• Netto-EU-Beitrag: € 183 454,80
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; Vereinigtes Königreich
• Region: East of England › East Anglia › Cambridgeshire CC
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 183 454,80