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Continuous self-assembly using enzyme mediated supramolecular switching

Objective

Supramolecular chemistry has resulted in truly sophisticated architectures, many of which are able to exert specific functions, as well as to change and adapt in response to external stimuli. So far, however, artificial structures with a similar functional complexity as living self-assembled systems are lacking. This is because nearly all current supramolecular systems are in thermodynamic equilibrium or kinetically trapped states. Living systems, on the other hand, operate far from equilibrium in so-called dissipative steady states, and continuously consume energy to keep their structure and function. Mimicking nature, here we propose to prepare dissipative self-assembled steady states of synthetic discotic molecules, controlled by competitive enzymatic pathways (phosphorylation / dephosphorylation), in which the supramolecular assemblies are kept far from equilibrium by a continuous perturbation i.e. the influx of a chemical fuel. We expect to get fundamentally new insights into non-equilibrium self-assembly, opening the door to truly adaptive, self-healing, life-like complex artificial systems. The candidate will be trained in a promising new research area in one of the hotspots for supramolecular chemistry in Europe, which would be a great stepping stone for his future independent research career.
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Coordinator

UNIVERSITE DE STRASBOURG

Address

Rue Blaise Pascal 4
67081 Strasbourg

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 173 076

Project information

Grant agreement ID: 658190

  • Start date

    24 March 2015

  • End date

    23 March 2017

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 173 076

  • EU contribution

    € 173 076

Coordinated by:

UNIVERSITE DE STRASBOURG

France