Objective The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 μm: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diameter (g-ratio) - a surrogate measure for its conductance speed. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging, can detect but not determine the origin of microstructural changes, whereas MWMI will both detect microstructural changes and identify their origin (e.g. whether learning leads to axonal reorganization or myelination). To facilitate MWMI, 3 major methodological innovations will be developed: (a) Advanced biophysical models: Unlike existing biophysical models (e.g. axonal diameter model), which are ill posed due to the restriction to one qMRI mechanism, MWMI will combine 4 different qMRI mechanisms (relaxometry, diffusion MRI, magnetization transfer, and proton density imaging) to better condition its models. (b) Spatial integration: Novel physically-informed artifact correction methods will allow spatial integration of high-quality maps from 4 different qMRI techniques with sub-voxel accuracy. (c) Mesoscopic resolution: Unlike standard biophysical models and qMRI, the unprecedented resolution of MWMI will allow estimating micro-scale metrics within the white matter that are unbiased by partial volume effects.The pain circuit, which is a fundamental and well-described sense, will be used to demonstrate the feasibility of MWMI. Longitudinal MWMI be performed to measure micro-scale correlated of nociceptive long-term habituation in the spinal cord, the first and crucial anatomical structure associated with pain. Fields of science natural sciencesbiological sciencesneurobiologyengineering and technologymaterials engineeringfibersengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingnatural sciencesbiological scienceshistology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Net EU contribution € 171 460,80 Address Martinistrasse 52 20251 Hamburg Germany See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 171 460,80
