Periodic Reporting for period 1 - LUMIMAGNET-NANO (Multifunctional luminescent and magnetic nanoparticles for advanced biomedical applications)
Reporting period: 2015-05-18 to 2017-05-17
- Synthesis and characterization of MxFe(3-x)O4 (M=Mn, Co, Ni, Zn) ferrite nanoparticles synthetized by two different approaches: a chemical route and biomineralization by magnetotactic bacteria.
- Functionalization of the magnetic nanoparticles to incorporate luminescent functionalities.
- Study of the heating properties of the magnetic nanoparticles when they are exposed to an alternating magnetic field, and potential application in magnetic hyperthermia.
The research performed in this six months within the Lumimagnet Nano project include:
- Synthesis of monodisperse doped MxFe(3-x)O4 ferrite nanoparticles by a high-temperature solution phase reaction of Fe, Mn, Ni or Zn precursors in the presence of oleic acid and oleylamine.
- Culture of Magnetospirillum gryphiswaldense bacteria and production of Fe3O4 magnetosomes doped with Co, Ni and Mn.
- Characterization of the magnetic nanoparticles by transmission electron microscopy, vibrating sample magnetometry and infrared spectroscopy.
- In-vitro study of the cytotoxicity of the magnetosomes and their application for magnetic hypertermia.
The main results achieved so far are:
- We demonstrate that in-vitro hypertermia treatment with magnetosomes cause efficient viability decrease and growth inhibition in ANA-1 macrophage cells. We are currently writing a paper with these results which will be submitted soon for publication.
- The results obtained in collaboration with the University of South Florida about the heating efficiency in multi-functional manganese ferrite/graphene oxide nanostructures have just been accepted for publication as a paper in the journal Nanotechnology.
- We submitted a proposal entitled ""X-ray absorption near edge structure (XANES) study on monodisperse MxFe3-xO4 nanoparticles obtained by synthetic and biological routes"" to both ALBA and ESRF synchrotron facilities. We have been granted with 15 shifts of beamtime in ALBA (9-14 February 2016) and 12 shifs of beamtime in ESRF (6-10 July 2016). The XANES experiments at the K-edge of both Fe and dopant M ions will provide information not only on the oxidation state of Mn, Fe, Co, Ni and Zn ions, but also on their local environment, particularly on the site symmetry. This characterization will be extremely helpful from both fundamental and applied points of view."
The fellow collaborated with a presentation at the Science exhibition week (Semana de la Ciencia) held in Bilbao in November 2015.