Antibacterial (Nano)medicines Development

Projektinformationen

AND

ID Finanzhilfevereinbarung: 659121

DOI 10.3030/659121

Abgeschlossenes Projekt

EK-Unterschriftsdatum 18 März 2015

Startdatum 1 April 2015

Enddatum 31 März 2017

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 165 598,80

EU-Beitrag € 165 598,80

Koordiniert durch

WAGENINGEN UNIVERSITY
Netherlands

Ziel

Despite the investment of billions of euros, there has been an inexorable decline in the discovery of new antibiotics over the last decades. In this individual fellowship (IF) application we propose a strategy to develop bacterial histidine-kinase (HK) inhibitors targeted at the catalytic and ATP-biding domain (CA) as novel broad-spectrum antibacterial (nano)medicines. Furthermore, putative mechanism of resistance to HK inhibitors and known antibiotics will be studied and novel antibacterial drug targets will be identified by using transposon insertion mutant libraries (Tn-libraries) to identify mutations involved in intrinsic resistance to antibiotics and/or leading to increased sensitivity to existing antibiotics in multi-drug resistant (MDR) strains.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › multidrug resistance
• medical and health sciences › health sciences › public health › epidemiology › zoonosis
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

WAGENINGEN UNIVERSITY

• Netto-EU-Beitrag: € 165 598,80
• Adresse: DROEVENDAALSESTEEG 4 ; 6708 PB Wageningen ; Niederlande
• Region: Oost-Nederland › Gelderland › Veluwe
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 165 598,80