Obiettivo This project develops a continuous flow microprocess for the synthesis of pure vitamin D3 from 7-dehydrocholesterol. Such approach will be achieved by applying a massive and combined photo-high-T intensification. Such conditions are only possible by employing microreactors according to Novel Process Windows postulates: The aim is to boost the reaction kinetics both by providing a high photon number density and through thermal intensification. In addition, supercritical conditions will be tested as third intensification option. Besides the normal time-invariant, continuous photon exposure, a new photochemical approach based on intense LED-photo-pulses will be tested to enhance the selectivity. To have a full process scheme covered, a continuous micro-plug-flow crystallization operating at fast mixing, short residence time and supersaturated conditions will be developed.Vitamin D3 is a very important nutrient needed to prevent all types of disease. As its deficiency is now recognized in the developed world, a significant increase demand in the market is expected. That is why it is envisaged a multiple impact of this project mainly in European society, but also for pharmaceutical companies and SMEs, representing for both a ‘Window of Opportunity’. Particularly photo-high-T could be also tested in other photochemical reactions; such as the synthesis of vitamin D2 or, by using other photocatalysts such as TiO2, in the N-ethylation of benzylamine.This multidisciplinary proposal includes Life-Cycle-Assessment (LCA) to holistically evaluate in ex-ante fashion different process intensification scenarios. At the project end, LCA will benchmark the flow achievements to the current batch production, looking towards its industrial transfer. For the fellow, this proposal means an extension of his previous research, but with novel and challenging additional aspects,providing with a range of training options in research and transferable skills for building his independent career. Campo scientifico natural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencesphysical chemistryphotochemistrysocial sciencessociologyindustrial relationsautomationnatural sciencesphysical sciencesopticslaser physicsnatural sciencesphysical sciencestheoretical physicsparticle physicsphotons Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2014 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-CAR - CAR – Career Restart panel Coordinatore TECHNISCHE UNIVERSITEIT EINDHOVEN Contribution nette de l'UE € 177 598,80 Indirizzo GROENE LOPER 3 5612 AE Eindhoven Paesi Bassi Mostra sulla mappa Regione Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 177 598,80
