Periodic Reporting for period 1 - C-Xaq (Cross-Coupling (C-X): Pioneering Mild Aqueous Cross-Coupling Methodologies to Enable Selective Functionalisation and Diversification of Halogenated Natural Products)
Reporting period: 2015-05-01 to 2017-04-30
1) Development of mild aqueous conditions for the selective cross-coupling of small (low risk) then NP embedded (medium risk), aromatic halides.
2) Development of mild aqueous Suzuki-Miyaura cross-coupling conditions compatible with living cells in a bioorthogonal manner
This interdisciplinary research has resulted in two major manuscripts that we submitted to leading journals (one to Chemical Science (online) and one to Nature Communications (accepted)). These manuscripts are a credit to the quality and novelty of the research that we have been driving forward. Importantly, we have contributed to develop the medicinal chemistry research area significantly beyond state-of-the-art as our methods can be successfully applied for the synthesis of relevant new to nature natural products analogues which are important to the health and well-being of society.
Furthermore, I had the opportunity to disseminate such important results in very prestigious events:
• 253rd ACS National Meeting & Exposition – Advanced Materials, Technologies, Systems & Processes,
2nd- 6th April 2017, San Francisco, USA
• “67th Lindau Nobel Laureate Meeting, dedicated to Chemistry”
25th-30th June 2017, Lindau, Germany (selected candidate)