Periodic Reporting for period 1 - KCs and Gut Antigens (Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens)
Reporting period: 2015-05-01 to 2017-04-30
The main findings from this project have been published (see below) and either have been or will be presented at an array of scientific meetings (see below). In addition, we are communicating the results to the public through participation in the Institute’s Biotechday, which will be held this year in October on the theme “Goed om (w)eten” (Good to know/eat).
- CL Scott et al., Bone marrow derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nature Communications. 2016. IF 11.329
- M Guilliams* and CL Scott*. Does Niche competition determine the origin of tissue-resident macrophages? Nature Reviews Immunology. 2017. IF 39.416 *co-corresponding authors.
- M Guilliams*, CA Dutertre*, CL Scott* et al., Unsupervised high dimensional analysis aligns dendritic cells across tissues and species. Immunity 2016. IF 24.082 *co-first authors
- CL Scott*, B Soen* et al., The transcription factor Zeb2 regulates the development of conventional and plasmacytoid DCs by repressing Id2. JEM 2016. IF 11.240 *co-first authors
- D Sichien, BN Lambrecht, M Guilliams & CL Scott. Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues. Mucosal Immunology. 2017. IF 7.374.
- D Sichien, CL Scott et al., IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid DCs respectively. Immunity. 2016. IF 24.082
- K Van Der Borght, CL Scott et al., Myocardial Infarction primes autoreactive T cells through activation of dendritic cells. Cell Reports. 2017. IF 7.870.
- L Van de Laar et al., Yolk-sac macrophages, foetal liver and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity. 2016. IF 24.082. (Middle author)
- CC Bain et al., Long lived self-renewing bone marrow derived macrophages displace embryo-derived cells to inhabit adult serous cavities. Nature Communications. 2016. IF 11.329. (Middle author)
1. CFCD 2017 Paris, France - http://www.cfcd.fr/meeting/program.html
2. SFI 2017 Reims, France - http://www.alphavisa.com/sfi/2016/
3. ESCI 2017 Genoa, Italy - http://esci2017.grupposymposia.it
4. VIB Macrophage Symposium 2017 Ghent Belgium
5. Immunological Disease and Translation Resolution Summit 2016, Shanghai 2016
6. Ghent Gut Immunology Group Meeting 2015, Ghent Belgium
Selected Short Talks
1. International Dendritic Cell Symposium (DC2016) – Shanghai
2. International Congress of Immunology (ICI) 2016 – Melbourne
3. 16th International Congress of Mucosal Immunology (ICMI) 2015 – Berlin
4. Dendritic Cells and Macrophages Reunited 2015 – Keystone
1. Mononuclear Phagocytes in Health, Immune Defense and Disease 2017 – Keystone
Our analysis demonstrating that genuine KCs can be derived from bone marrow monocytes rather than embryonic progenitors (Scott et al, 2016. Nature Communications) and work I contributed to highlighting that this is also true for alveolar macrophages in the lung (Van de Laar et al., 2016. Immunity) opens the door for monocyte based cellular therapy whereby defective macrophage populations can be replaced by administering monocytes in the right environment. Monocytes can be easily isolated from the blood making this a feasible potential strategy in the future.
With the new tools generated as part of this fellowship, we have also generated some more preliminary data regarding the role of KCs in mounting immune responses to orally administered antigens and local factors emanating from the gut. Based on this, we have secured further funding to continue this research which we hope will further extend our knowledge of how the immune systems responds to intestinal antigens and how we can begin to manipulate the system to prevent/treat disease including food intolerances.