Objectif Atherosclerosis is a disease of the arteries. It leads to the formation of atherosclerotic plaques (atheromas), which may disrupt the blood flow to target organs, leading to heart disease and stroke - the most common causes of death in developed countries. Cardiovascular imaging has traditionally focused on the anatomy of the atherosclerotic plaque; however, the degree of vessel narrowing caused by the plaque isn’t the only characteristic that can determine the clinical outcome. Indeed, the cellular and molecular composition of the atheroma can indicate whether the plaque might cause complications. In particular the local immune-inflammatory response participates from the onset of the pathology through its progression, up to clinical manifestations. Consequently the development of innovative approaches for the molecular imaging of inflammation in atherosclerosis would be key to improve diagnosis and treatment.In the last decade molecular imaging has emerged as a novel tool for the visualization and measurement of biological processes in atheromas. Various imaging technologies have been developed; however, each approach presents severe weaknesses. Surface Enhancement Raman Spectroscopy (SERS) is developing as an effective molecular imaging optical modality in biomedicine because it offers many advantages over traditional technologies, including better sensitivity, and a superior multiplexing capability. Therefore, the primary aim of the present proposal is to develop innovative, highly-sensitive and selective but relatively affordable SERS-based system to measure inflammation in atherosclerotic vessels. I will use nanoparticles (NPs), small metallic particles, which possess the ability to recognise inflammatory markers, as imaging probes. When a light source is shone on these NPs, they can be detected by SERS. The secondary aim is to customise the NPs to enable local treatment of the pathology. The proposed approaches will offer new ways to manage atherosclerosis. Champ scientifique medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepathologyengineering and technologynanotechnologynano-materialsnatural sciencesphysical sciencesopticsspectroscopy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2014 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur UNIVERSITY OF GLASGOW Contribution nette de l'UE € 183 454,80 Adresse UNIVERSITY AVENUE G12 8QQ Glasgow Royaume-Uni Voir sur la carte Région Scotland West Central Scotland Glasgow City Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 183 454,80
