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Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche

Objetivo

ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them into a new immune-isolation and biomimetic scaffolding approach for islet and cell transplantation in diabetes treatment. ELASTISLET’s starting point is a highly innovative and versatile family of superior biomaterials, the Elastin-like Recombinamers (ELRs). Those innovative materials will be combined with the most cutting-edge encapsulation technologies, such as reactive LbL. ELASTISLET relies on the most innovative ideas taken from synthetic biology, nanobiotechnology and molecular and cellular biology to build the ideal niche for islet/cell encapsulation and transplantation.
ELASTISLET main objective is to achieve a functional coating that fulfils, first, the basic requirements of optimal biocompatibility and physical properties (permselectivity) but, second, generate a capsule that can promote an intense and directed cross talk through all cell-material interfaces involved: the implant-surrounding tissue (outer) interface and cargo cells-capsule (inner) interface. At the end, a capsule that is able not only to cloak its content and isolate it from the immune rejection but that it is able to biologically interact with the surrounding tissues and its cargo simultaneously in a way that the implanted capsule will immediately interact and fuse with the surrounding tissues creating a real continuity of the extracellular matrix from the core of the capsule to the surrounding hosts tissues and procuring adequate nutrient supply. That will provide a physiologically ideal biomimetic environment for the implanted islets/cells to survive and function in the long term without perceiving a foreign, unusual or hostile environment.

Ámbito científico

  • /ciencias médicas y de la salud/ciencias de la salud/salud pública y medio ambiental/prevención de la epidemia/inmunización
  • /ciencias naturales/ciencias biológicas/biología sintética
  • /ciencias médicas y de la salud/medicina clínica/trasplante
  • /ciencias médicas y de la salud/medicina básica/inmunología

Convocatoria de propuestas

H2020-NMP-2014-two-stage
Consulte otros proyectos de esta convocatoria

Régimen de financiación

RIA - Research and Innovation action

Coordinador

UNIVERSIDAD DE VALLADOLID
Dirección
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
España
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 773 555,97

Participantes (11)

UNIVERSIDADE DO MINHO
Portugal
Aportación de la UE
€ 301 121,88
Dirección
Largo Do Paco
4704 553 Braga
Tipo de actividad
Higher or Secondary Education Establishments
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Aportación de la UE
€ 303 125
Dirección
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Tipo de actividad
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Aportación de la UE
€ 645 750
Dirección
Spitalgasse 23
1090 Wien
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAT BASEL
Suiza
Aportación de la UE
€ 0
Dirección
Petersplatz 1
4051 Basel
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PERUGIA
Italia
Aportación de la UE
€ 688 579,01
Dirección
Piazza Dell Universita 1
06123 Perugia
Tipo de actividad
Higher or Secondary Education Establishments
PROMOSCIENCE SRL
Italia
Aportación de la UE
€ 262 450
Dirección
Localita Padriciano 99
34012 Trieste
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
España
Aportación de la UE
€ 489 000
Dirección
Paseo De Belen 11
47011 Valladolid
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NCARDIA AG
Alemania
Aportación de la UE
€ 341 875
Dirección
Nattermannallee 1
50829 Koln
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASPHALION SL
España
Aportación de la UE
€ 222 500
Dirección
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UPPSALA UNIVERSITET
Suecia
Aportación de la UE
€ 831 597,51
Dirección
Von Kraemers Alle 4
751 05 Uppsala
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSIDADE DE AVEIRO
Portugal
Aportación de la UE
€ 354 940,63
Dirección
Campus Universitário De Santiago
3810-193 Aveiro
Tipo de actividad
Higher or Secondary Education Establishments