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Unconventional Bifunctional Catalysts

Unconventional Bifunctional Catalysts

Objective

The development of sustainable chemical processes is one of the most important features in modern chemistry. It has become a key research area worldwide providing solutions to important societal demands by optimizing the use of natural resources and minimizing waste and environmental impact. Among the relevant methods for achieving this goal, catalysis represents a key and central approach. Both Organocatalysis and Metal Catalysis have emerged as solutions to the problems in this context. In this field, the progress of a novel bifunctional organocatalyst that could increase the number of different activations, and therefore the synthesis of valuable enantio-enriched molecules, would be highly desirable. Especially important, but still unknown, are the bifunctional-catalysts based on a Neutral Coordinate Organocatalyst and Photo-Organocatalysts. This proposal aims to develop two new unconventional approaches for the synthesis of bifunctional organocatalysts.
The first one is based on the development of new Bifunctional Neutral Coordinate Organocatalyst and their application to the synthesis of biologically relevant compounds. I propose to use these bifunctional catalysts to promote the dual activation of silyl reagents and suitable electrophiles. This approach constitutes an unconventional way to synthesize asymmetric molecules and has no precedent in the literature.
The second section of this proposal explores the photo-activation-bifunctional organocatalyst. I propose the design and application of new metal-free Bifunctional Photo-Organocatalysts which are able to chemically and photo-activate the substrate simultaneously in an asymmetric manner.
This project has the potential to change the general view of asymmetric Neutral Coordinate Organocatalyst and Photo-catalysis as we know it today. These unconventional bifunctional would be incorporated into the privileged catalyst library for its applications in new asymmetric transformations.
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Host institution

UNIVERSIDAD AUTONOMA DE MADRID

Address

Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 987 750

Beneficiaries (1)

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UNIVERSIDAD AUTONOMA DE MADRID

Spain

EU Contribution

€ 1 987 750

Project information

Grant agreement ID: 647550

Status

Ongoing project

  • Start date

    1 September 2015

  • End date

    31 August 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 987 750

  • EU contribution

    € 1 987 750

Hosted by:

UNIVERSIDAD AUTONOMA DE MADRID

Spain